benzoxazole | Page 10 of 670 | Heterocyclic Building Blocks-Benzoxazole

Zhao, LiJun et al. published their research in Science China: Chemistry in 2013 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Reference of 99586-31-9

3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibitors was written by Zhao, LiJun;Zhang, LiangRen;Lei, Ming. And the article was included in Science China: Chemistry in 2013.Reference of 99586-31-9 This article mentions the following:

Transthyretin (TTR), a plasma protein with a tetramer structure, could form amyloid fibril associated with several human diseases through the dissociation of tetramer and the misfolding of monomer. These amyloidogenesis can be inhibited by small mols. which bind to the central channel of TTR. A number of small mols. like 2-arylbenzoxazoles (ABZ) analogs are proposed as promising therapeutic strategy to treat amyloidosis. In this work, comparative mol. field anal. (CoMFA) and comparative mol. similarity indexes anal. (CoMSIA) three-dimensional quant. structure-activity relationship (3D-QSAR) and docking studies were performed on series of 2-arylbenzoxazoles (ABZ) and linker-Y analogs to investigate the inhibitory activities of TTR amyloidogenesis at at. level. Significant correlation coefficients for ABZ series (CoMFA, r² = 0.877, q² = 0.431; CoMSIA, r² = 0.836, q² = 0.447) and those for linker-Y series (CoMFA, r² = 0.828, q² = 0.522; CoMSIA, r² = 0.800, q² = 0.493) were obtained, and the generated models were validated using test sets. In addition, docking studies on 6 compounds binding to TTR were performed to analyze the forward or reverse binding mode and interactions between mols. and TTR. These results from 3D-QSAR and docking studies have great significance for designing novel TTR amyloidogenesis inhibitors in the future. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Reference of 99586-31-9).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tehrani, Kourosch Abbaspour et al. published their research in Journal of Agricultural and Food Chemistry in 2002 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 5676-58-4

Thermal Degradation Studies of Glucose/Glycine Melanoidins was written by Tehrani, Kourosch Abbaspour;Kersiene, Milda;Adams, An;Venskutonis, Rimantas;De Kimpe, Norbert. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Application of 5676-58-4 This article mentions the following:

Nondialyzable and water-insoluble melanoidins, isolated from a glucose/glycine model reaction mixture, which was prepared in a standardized way according to the guidelines of the COST Action 919, were heated at different temperatures ranging from 100 to 300 °C. Among the volatile compounds, which were analyzed by solid-phase microextraction and GC-MS, pyrazines, pyridines, pyrroles, and furans were detected. In general, total amounts of volatile compounds increased with the temperature When water-insoluble melanoidins were heated, especially at higher temperatures, this resulted in a higher diversity of isolated compounds For furans, pyrroles, pyrazines, and carbonyl compounds, a maximum was observed in the case of high mol. weight melanoidins around 200-220 °C. Pyridines and total oxazoles, however, were generated in higher yields with increasing temperatures Thus, the possibility of producing some flavor-significant volatiles from heated standard melanoidins at temperatures relevant to food preparation and contribute to the flavor aspects originating from melanoidins. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Leng, Yuting et al. published their research in Chinese Journal of Chemistry in 2011 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Product Details of 99586-31-9

Cyclopalladated ferrocenylimine catalyzed chlorination of 2-arylbenzoxazoles was written by Leng, Yuting;Yang, Fan;Wu, Yangjie;Li, Ke. And the article was included in Chinese Journal of Chemistry in 2011.Product Details of 99586-31-9 This article mentions the following:

An efficient and facile protocol for palladacycle-catalyzed chlorination of 2-arylbenzoxazoles was developed. The results represent the first examples involving the palladacycle as the catalyst for such chlorination. This chlorination was not a ligand-directed ortho-C-H activation, but an electrophilic substitution process at the para-position of the nitrogen atom in the benzo ring of benzoxazole moiety, the regiochem. of which had been confirmed by HMBC spectral anal. The catalytic system could tolerate various halogen atoms, such as F, Cl and Br, affording the corresponding products in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Product Details of 99586-31-9).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Radanovic, Dusan J. et al. published their research in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Gold(III) complexes with imidazole, benzoxazole, purine and pyrimidine derivatives was written by Radanovic, Dusan J.;Matovic, Zoran D.;Ponticelli, Gustavo;Scano, Paola;Efimenko, Inessa A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.SDS of cas: 5676-58-4 This article mentions the following:

The synthesis and characterization of Au^III complexes with several heterocyclic ligands are reported. The compounds are [AuX₃(L)], where L = N-methylimidazole (N-MeIz), N-ethylimidazole (N-EtIz), N-propylimidazole (N-PrIz), benzoxazole (BO), 2-methylbenzoxazole (2-MeBO), 2,5-dimethylbenzoxazole (2,5-diMeBO), 2-aminopyrimidine (2-APm), 4(6)-hydroxypyrimidine [4(6)-hydrPm] or hypoxanthine (Hypox) and X = Cl or Br. Elemental anal., conductivity measurements and spectral studies were used for the characterization of the complexes. A square-planar geometry with N-bonded heterocyclic ligands is suggested. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Hung, Su-Chun et al. published their research in Analytical Biochemistry in 1996 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Related Products of 5676-58-4

Cyanine dyes with high absorption cross section as donor chromophores in energy transfer primers was written by Hung, Su-Chun;Ju, Jingyue;Mathies, Richard A.;Glazer, Alexander N.. And the article was included in Analytical Biochemistry in 1996.Related Products of 5676-58-4 This article mentions the following:

Energy transfer (ET) fluorescent primers are significantly superior to single dye-labeled primers for DNA sequencing and multiplex genetic analyses (Ju, J. et al., 1996). We describe here ET primers in which a donor chromophore with a large absorption cross section but a low fluorescence quantum yield is exploited to increase the Stokes-shifted fluorescence emission of acceptor dyes. The new ET primers have 3-(ε-carboxypentyl)-3′-ethyl-5,5′-dimethyloxacarbocyanine (CYA; ε_M⁴⁸⁸ ^nm 142,000 M^-1cm^-1) at the 5′-end as a common energy donor, and fluorescein or rhodamine derivatives (FAM, R6G, TAMRA, and ROX), attached to a modified thymidine 10 bases away within the primer sequence, as acceptors. With 488-nm excitation, the fluorescence emission intensity of these 4 ET primers is 1.4-24-fold stronger than that of the corresponding primers labeled only with the single acceptor dye. When compared with the corresponding ET primers with a fluorescein derivative (FAM; ε_M⁴⁸⁸ ^nm 60,000 M^-1 cm^-1) as donor, the fluorescence emissions of primers with CYA as donor and FAM, R6G, TAMRA, and ROX as acceptors are 0.8-, 1.0-, 1.7-, and 1.7-fold, resp., as intense. The low fluorescence quantum yield of the CYA donor resulted in distinct fluorescence signals for the DNA-sequencing fragments with much lower crosstalk between the 4 detection channels than that seen with ET primers based on a FAM donor. With single-stranded M13mp18 DNA as the template, the CYA ET primers provided DNA sequences on a 4-color capillary sequencer with 100% accuracy in the first 500 bases. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Related Products of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Matovic, Zoran D. et al. published their research in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.COA of Formula: C9H9NO

Gold(I) complexes of azoles was written by Matovic, Zoran D.;Radanovic, Dusan J.;Ponticelli, G.;Scano, P.;Efimenko, I. A.. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 1994.COA of Formula: C9H9NO This article mentions the following:

(Di-Me sulfide)AuCl reacts with azoles to give adducts [LAuX]₂ [L = N-methylimidazole (N-MeIm), N-ethylimidazole (N-EtIm), N-propylimidazole (N-PrIm), 2-methylbenzoxazole (2-MeBO) and 2,5-dimethylbanzoxazole (2,5-diMeBO); X = Cl or Br] which were characterized analy. and spectroscopically, including ¹H-n.m.r.I.r. and Raman studies showed that the compounds were binuclear with bridging halogen atoms. A nitrogen-containing ligand was coordinated to nitrogen N(3) atom of the azole ring in monodentate fashion. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sirgamalla, Rambabu et al. published their research in Chemical Data Collections in 2020 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C13H8BrNO

Copper-catalyzed an efficient synthesis, characterization of 2-substituted benzoxazoles, 2-substituted benzothiazoles derivatives and their anti-fungal activity was written by Sirgamalla, Rambabu;Kommakula, Ashok;Konduru, Sumalatha;Ponakanti, Ravindar;Devaram, J.;Boda, Sakram. And the article was included in Chemical Data Collections in 2020.Formula: C13H8BrNO This article mentions the following:

An efficient synthesis of 2-substituted benzoxazoles, (I) (R = H, Me, Cl, NO₂; R1 = 3-F, 2-OH, 4-Me, 4-OMe, etc.) and 2-substituted benzothiazole (I) (R = H, Me, Cl, NO₂; R1 = 4-F, 4-Me, 4-OMe, 4-NO₂, etc.) from condensation of 2-aminophenol, and 2-aminothiophenol react with various aldehydes in Cu₂O in the presence of DMSO oxidant system has been developed. This reaction is operationally simple, proceeds with copper catalysts, tolerates a wide range of functionalities, and provides elemental anal. (C, H, N) providing desired products in good to excellent yields. All the synthesized compounds were screened for anti-fungal activity. Among all the compounds shows good activity I (R = H, R₁= 4-OMe; R = Me, R₁= 4-OMe; R = Cl, R₁= 4-OMe; R = Cl, R₁= 4-OH), (III) and (II) (R = H, R₁= 4-F; R = H, R₁= 4-OMe) shows equal to reference drug. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zhang, Xiaohui et al. published their research in Tetrahedron in 2015 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Name: 2,5-Dimethylbenzoxazole

Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement was written by Zhang, Xiaohui;Huang, Ruofeng;Marrot, Jerome;Coeffard, Vincent;Xiong, Yan. And the article was included in Tetrahedron in 2015.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

A Beckmann-type rearrangement of o-hydroxy and o-aminoaryl N-H ketimines was developed to prepare benzoxazoles and N-Ts benzimidazoles, resp. The ketimine derivatives were easily prepared by condensation of ammonia with the corresponding ketones and (diacetoxyiodo)benzene acts as an efficient oxidant to trigger the [1,2]-aryl migration towards the formation of the desired heterocycles. Depending on the substitution pattern, the results revealed another mechanistic pathway through which benzisoxazoles or 1H-indazoles could be formed. The Beckmann-type rearrangement strategy was applied to the synthesis of benzimidazole-containing biorelevant targets such as chlormidazole and clemizole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tang, Jun et al. published their research in Industrial & Engineering Chemistry Research in 2020 | CAS: 99586-31-9

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Related Products of 99586-31-9

New Approach for Controllable Synthesis of N-MnO_x Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis was written by Tang, Jun;Cao, Yali;Ruan, Fei;Li, Fengfeng;Jin, Yangxin;Ha, Minh Ngoc;Han, Xinya;Ke, Qingping. And the article was included in Industrial & Engineering Chemistry Research in 2020.Related Products of 99586-31-9 This article mentions the following:

Herein, the novel approach for controlled synthesis of nitrogen doped MnO_x (denoted as N-MnO₂, N-Mn₅O₈ and N-Mn₃O₄) by adjusting the heteroatom nitrogen amount is reported. It was shown that N-MnO₂ catalyst is a sustainable and cost-effective heterogeneous catalyst for condensation of 2-aminophenols and o-phenylenediamine with alcs. to afford the corresponding benzoxazoles and benzimidazole, resp. The N-MnO₂ catalyst displayed >99.9% yield for benzoxazole synthesis under room temperature and no decay (10 cycles), compared with the negligible activity (∼0%) for MnO₂ catalysts. X-ray absorption spectroscopies and exptl. studies uncovered that oxygen vacancies, generated by heteroatom N doping, act as the key role for promoting intramol. oxidative dehydrogenation of alc. and 2-aminophenol derivatives to directly yield desired products. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Related Products of 99586-31-9).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zdanovich, V. I. et al. published their research in Doklady Akademii Nauk SSSR in 1965 | CAS: 5676-58-4

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Related Products of 5676-58-4

Transfer of the substituent effect in series of cis- and transcinnamic acids was written by Zdanovich, V. I.;Parnes, Z. N.;Kursanov, D. N.. And the article was included in Doklady Akademii Nauk SSSR in 1965.Related Products of 5676-58-4 This article mentions the following:

Potentiometric determination of dissociation constants was performed for the cis- and trans-cinnamic acids and their benzoic acid analogs in 49% EtOH at 25°. The following K × 10⁶ were found for: benzoic acids, trans-cinnamic acid and cis-cinnamic acids, resp. with indicated substituents: H 1.25; 1.05 (m. 135.2-5.7°); 2.79 (m. 67-8°); p-O₂N 12.0; –; –; m-O₂N 13.7; 3.82 (m. 205-6°); 6.40 (m. 159-9.5°); p-Cl 2.38; 2.00 (m. 249.5-9.8°); 4.09 (m. 112.8-14°); p-Br 3.65; 1.92 (m. 264.7-5.5°); 4.02 (m. 127.6-8.5°); p-MeO 0.68; 0.70 (m. 188-8.2°); 1.78 (m. 68.8-9.7°); p-H₂N 0.17; –; –; p-Me₂N –; 0.32 (m. 118-20°); –. The following Hammett reaction constants were determined: ester hydrolysis trans isomer 0.540; cis isomers 0.461; dissociation of the acids trans isomers 0.539; cis isomers 0.422. Transfer of the substituent effects is more effective in trans-cinnamic acids than in the cis isomers. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem