Category: benzoxazole

Structure and reactivity of benzoxazoles: carbon-13 nuclear magnetic resonance study was written by Llinares, Jeanine;Galy, Jean Pierre;Faure, Robert;Vincent, Emile Jean;Elguero, Jose. And the article was included in Canadian Journal of Chemistry in 1979.Formula: C9H9NO This article mentions the following:

Thirty-four benzoxazoles, oxazole, and 10 o-aminophenols were studied by ¹³C NMR spectroscopy. All the signals are attributed to substituent effects. The structures of the products obtained by the nitration of benzoxazole were determined by ¹³C NMR. The shifts induced by substitution at the 2 position are discussed as a function of an empirical model by using the structural parameters F, R, and Q^*. Azido-tetrazole equilibrium (N₃ in position 2) and prototropic tautomerism (NH₂, OH, and SH in position 2) are also discussed. The chem. shifts and coupling constants of oxazole and unsubstituted benzoxazole are compared. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Homo- and Heteroannulation of sp³ C-H Bonds in Acetophenones for Divergent Synthesis of Thienothiazoles was written by Pham, Phuc H.;Nguyen, Khang X.;Pham, Hoai T. B.;Nguyen, Tung T.;Phan, Nam T. S.. And the article was included in Organic Letters in 2019.Safety of 2,5-Dimethylbenzoxazole This article mentions the following:

A synthesis of fused thieno[3,2-d]thiazoles I (R = H, Me, OMe, etc.) via direct functionalization of C(sp³)-H bonds in acetophenones was reported. The transformation is divergent to afford either 2-phenylbenzo[4,5]thieno[3,2-d]thiazoles or benzo[4,5]thieno[3,2-d]thiazol-2-yl(phenyl)methanones. Cross-coupling of acetophenones with C-H bonds in phenylacetic acids, methylazaarenes, and aldehydes was also feasible. Excellent tolerance of functionalities was observed This method marks a rare functionalization of C(sp³)-H bonds in acetophenones to obtain heterocycles in the absence of pre-functionalized oxime esters. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Safety of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Safety of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

DMF-Assisted Radical Cyclization of o-Isocyanodiaryl Ethers via 1,5-Aryl Migration: Construction of 2-Arylbenzoxazoles was written by Yuan, Sitian;Ye, Xiaoling;Cai, Jingyu;Song, Zhibin;Tan, Yuxing;Peng, Yiyuan;Ding, Qiuping. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: 99586-31-9 This article mentions the following:

A novel DMF-assisted radical cyclization of o-isocyanodiaryl ethers 2-CN-3-R¹-4-R² -5-R³ C₆HOR (R = 2-tert-butylphenyl, 2-phenylphenyl, pyridin-2-yl; R¹ = H, Me, Cl; R² = H, Me, Cl; R³ = H, Me) via 1,5-aryl migration has been developed for the synthesis of a series of 2-arylbenzoxazoles I and 2-phenyloxazolo[4,5-b]pyridine by the FeCl₃/TBHP/Et₃N catalytic system in DMF. However, N,N-dimethylbenzo[d]thiazole-2-carboxamide and N,N-dimethylbenzo[d]selenazole-2-carboxamide were obtained from the corresponding substrate 2-isocyanophenyl p-methoxyphenyl thioether and 2-isocyanodiphenyl selenoether under the same conditions. A possible mechanism may involve aryl 1,5-migration and DMF-assisted radical cyclization of o-isocyanodiaryl ethers I. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Recommanded Product: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Electronic and vibrational spectra of 2-chloro-and 2,5-dimethyl benzothiazole and 2,5-dimethyl benzoxazole was written by Agrawal, Saumya;Srivastava, R. L.;Shukla, M. M.. And the article was included in Acta Ciencia Indica, Physics in 1993.Related Products of 5676-58-4 This article mentions the following:

This paper contains the anal. and assignment of electronic absorption spectra of 2-chloro- and 2,5-di-Me benzothiazole and 2,5-di-Me benzoxazole in liquid and vapor state in the region 50000-28000 cm^-1 together with their IR absorption spectra in the region 40000-400 cm^-1. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Related Products of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Related Products of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Copper-Catalyzed Direct C-H Bond Arylation of Benzoxazoles with Anilines was written by Feng, Pengju;Ma, Guojian;Zhang, Tianyu;Wang, Changwei. And the article was included in Asian Journal of Organic Chemistry in 2018.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

An efficient and easily managed protocol was developed for the synthesis of 2-aryl-benzoxazoles/benzothiazoles I [R = H, 5-Me, 5-Cl, 5-Br, 5-CO₂Et; R¹ = 2-Me, 4-Cl, 3-Br, etc.; X = O, S; Y = CH, N] by using a copper-catalyzed C-H arylation reaction between benzoxazole derivatives and in situ generated aryl diazonium salts. Under the optimized conditions a wide variety of products I were selectively obtained in moderate to good yields. Diphenylamine and 2,3′-bipyridine were also obtained under the same reaction conditions by employing aniline and pyridin-3-amine resp., as the sole starting material. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Recommanded Product: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mesoporous Poly(melamine-formaldehyde): A Green and Recyclable Heterogeneous Organocatalyst for the Synthesis of Benzoxazoles and Benzothiazoles Using Dioxygen as Oxidant was written by Yang, Daoshan;Liu, Peng;Zhang, Ning;Wei, Wei;Yue, Mingbo;You, Jinmao;Wang, Hua. And the article was included in ChemCatChem in 2014.SDS of cas: 99586-31-9 This article mentions the following:

A simple, highly efficient, and sustainable strategy for the synthesis of benzoxazole and benzothiazole derivatives was developed by using inexpensive, green, readily available, and recyclable mesoporous poly(melamine-formaldehyde) as a green, heterogeneous organocatalyst. The corresponding substituted benzoxazoles and benzothiazoles were obtained in good to excellent yields by aerobic oxidation of o-substituted aminobenzenes with various aldehydes under dioxygen atm. The catalyst can be completely recovered through simple filtration to be reused more than six times without significant loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of N-octadecylsquarylium dye was written by Tanaka, Motoo;Sekiguchi, Tatsuo;Kawabata, Yasujiro;Nakamura, Takayoshi;Manda, Eiichiro. And the article was included in Nippon Kagaku Kaishi in 1987.Recommanded Product: 5676-58-4 This article mentions the following:

The synthesis of N-octadecylsquarylium dyes I (R = H, Me, OMe, Cl; X = CMe₂, S, Se) and II (R¹ = Me, Et; R₂ = H, Me, OH) was studied. A mixture of 2 mol N-octadecylated intermediate and 1 mol squaric acid was refluxed 24 h in 2:3 (volume) PhCl-1-pentanol (Method A), or heated 5 h at 160° in the presence of Nafion H resin (Method B). Method B gave better yields than method A. The yields of I were affected by the electronegativity of X and were in the order CMe₂ > Se > S > O. In the case of II good yields were attained for R² which was an electron-releasing substituent such as OH or Me. IR and NMR measurements revealed that I and II had sym. 1,3-bonded squarylium rings, consistent with the results of N-Me squarylium dyes reported by A. Treibs and K. Jacob (1966,1698). In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A Mild, Efficient and Reusable Solid Phosphotungstic Acid Catalyst Mediated Synthesis of Benzoxazole Derivatives: A Grinding Approach was written by Patil, Mahadeo R.;Yelamaggad, Aditya;Keri, Rangappa S.. And the article was included in Letters in Organic Chemistry in 2016.Application of 99586-31-9 This article mentions the following:

Herein, PTA catalyzed synthesis of 2-arylbenzoxazoles from 2-aminophenols and different aromatic aldehydes using a grinding strategy in excellent yield is reported. The use of this reusable catalyst under solvent-free conditions has made this protocol practical, environmentally friendly and economically attractive. The simple work-up procedure, the short reaction times, the mild reaction conditions, the high yields of products and the non-toxicity of the catalyst are other advantages of the present method. This protocol approaches combines the advantages of both focused library synthesis and diversity oriented synthesis because of the simplification of reaction protocol. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application of 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Nuclear magnetic resonance study of the benzoxazole derivatives was written by Okuda, Hisashi;Nagai, Makoto. And the article was included in Bulletin of the Chemical Society of Japan in 1967.HPLC of Formula: 5676-58-4 This article mentions the following:

The proton N.M.R. spectra of 2,5-dimethylbenzoxazole, 2,5,7-trimethylbenzoxazole, 2,5,6-trimethylbenzoxazole, 2 methyl-5-chlorobenzoxazole, and 2,4,5-trimethylbenzoxazole are recorded in CCl4 (or CDCl3) and in CF3COOH. In neutral solution, the chem. shifts are interpreted in terms of π-electronic charge ds., magnetic anisotropy of the O and N heteroatoms, and the elec. field effect. Protonation of the N heteroatom in acid solution shifts all of the protons to lower field. To account for the linear dependence of the chem. shifts, corrected for the elec. and anisotropy contributions, with calculated π-electron ds. a proportionality constant of 3.37 ppm./electron is needed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemical composition and anti-inflammatory activity of the essential oil of Nigerian Psorospermum tenuifolium (Hook. F.) was written by Zubair, M. F.;Oladosu, I. A.;Olawore, N. O.;Fakunle, C. O.. And the article was included in International Journal of Essential Oil Therapeutics in 2009.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

The chem. composition of the essential oils obtained by hydrodistillation from the leaves and roots of Psorospermum tenuifolium collected from North Central Nigeria were analyzed by GC and GC/MS. Twenty-nine compounds representing 93.54% of the leaf essential oil and thirteen compounds representing 83.63% of the root essential oil were determined The two types of oils were differentiated according to their main components. The major constituents of the leaf oil were linalool, α-terpineol,β-caryophyllene, 3-carene and α-gurjunene. The root oil was predominantly monoterpenes that included α-pinene, β-pinene, limonene and myrcene. The leaf essential oil was subjected to anti-inflammatory assay due to its higher number of compounds At 5.0 and 2.5 mg dose levels, the oil exhibited significant anti-inflammatory activity with an edema reduction of 92.3% and 76.9% resp., which was more effective than that demonstrated by a 0.25 mg dose of indomethacin. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem