Category: benzoxazole

Simple and efficient one-pot synthesis of 2-substituted benzoxazole and benzothiazole was written by Patil, Sachin S.;Bobade, Vivek D.. And the article was included in Synthetic Communications in 2010.Name: 2,5-Dimethylbenzoxazole This article mentions the following:

2-Substituted benzoxazole and benzothiazole were synthesized from condensation of aldehyde and 2-aminophenol or 2-aminothiophenol via a one-pot process using di-Et bromophoshonate and tert-Bu hypochlorite. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Name: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Name: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Deep eutectic solvent-catalyzed arylation of benzoxazoles with aromatic aldehydes was written by Tran, Phuong Hoang;Thi Hang, Anh-Hung. And the article was included in RSC Advances in 2018.SDS of cas: 99586-31-9 This article mentions the following:

A novel and efficient methodol. for the arylation of benzoxazoles with aromatic aldehydes catalyzed by deep eutectic solvent has been developed. The reaction smoothly proceeded with a wide range of substrates to give the desired products in high yields within short reaction time. Deep eutectic solvents are easily recovered and reused without significant loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9SDS of cas: 99586-31-9).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.SDS of cas: 99586-31-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions was written by Mohammadpoor-Baltork, Iraj;Khosropour, Ahmad R.;Hojati, Seyedeh F.. And the article was included in Monatshefte fuer Chemie in 2007.Computed Properties of C9H9NO This article mentions the following:

A series of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was efficiently synthesized from the reactions of o-aminophenols, o-aminothiophenol, o-phenylenediamines, and 2-amino-3-hydroxypyridine with orthoesters in the presence of catalytic amounts of Bi(III) salts, such as Bi(TFA)₃, Bi(OTf)₃, and BiOClO₄ · xH₂O under solvent-free conditions. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of relatively non-toxic catalysts. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Computed Properties of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Computed Properties of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Application of nano SnO₂ as a green and recyclable catalyst for the synthesis of 2-aryl or alkylbenzoxazole derivatives under ambient temperature was written by Vahdat, Seyed Mohammad;Raz, Shima Ghafouri;Baghery, Saeed. And the article was included in Journal of Chemical Sciences (Bangalore, India) in 2014.Synthetic Route of C9H9NO This article mentions the following:

Application of nano-SnO₂ as an efficient and environmentally benign catalyst was explored for the synthesis of 2-arylbenzoxalzole derivatives I [R = Ph, 2-HOC₆H₄, 2-MeOC₆H₄, 2-furyl, 3-Cl, 2-thienyl, etc., R¹ = H, Me, Cl, NO₂] or 2-alkylbenzoxazole derivatives I [R = H, Me, Et, R¹ = H, Me, Cl] via condensation reaction of 2-aminophenols with aryl aldehydes or orthoesters, resp. The SnO₂ nanocatalyst is reusable, cheap and eco-friendly. This catalyst offers several advantages including mild reaction conditions, high yield of products, lower catalyst loading and shorter reaction times with simple exptl. and isolation procedures. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Synthetic Route of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Silica-sulfuric acid catalyzed microwave-assisted synthesis of substituted benzoxazoles and their antimicrobial activity was written by Anand, M.;Ranjitha, A.;Himaja, M.. And the article was included in International Research Journal of Pharmacy in 2011.COA of Formula: C9H9NO This article mentions the following:

Benzoxazole derivatives were designed for a study of their biol. activity, the synthesis of the target compounds was achieved by a microwave-mediated method using sulfated silica (solid acid) as catalyst and ortho esters and 2-aminophenol derivatives as starting materials and the products thus obtained were confirmed by ¹H-NMR and MS. The title compounds were screened against Staphylococcus aureus, Escherichia coli, Candida albicans and Candida glabrata (yeast) and it was discovered that these compounds displayed antimicrobial activity in comparison with Trimethoprim and Miconazole. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles was written by Saha, Prasenjit;Ramana, Tamminana;Purkait, Nibadita;Ali, Ashif Md;Paul, Rajesh;Punniyamurthy, Tharmalingam. And the article was included in Journal of Organic Chemistry in 2009.COA of Formula: C13H8BrNO This article mentions the following:

The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramol. cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. E.g., cyclization of o-bromoaryl amidine I gave 95% benzimidazoles II. The procedure is exptl. simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9COA of Formula: C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.COA of Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A comparative study of symmetrical and unsymmetrical trimethine cyanine dyes bearing benzoxazolyl and benzothiazolyl groups was written by Shi, Quan-Quan;Sun, Ru;Ge, Jian-Feng;Xu, Qing-Feng;Li, Na-Jun;Lu, Jian-Mei. And the article was included in Dyes and Pigments in 2012.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:

Six sym. and unsym. trimethine cyanine dyes bearing benzothiazolyl and benzoxazolyl groups were synthesized. Their linear optical properties were studied. The variation of hetero atoms play an important role in the spectral properties of the dyes. Sequential replacement of the oxygen atom by the sulfur atom resulted in a change in shade from yellow to purple. In order to understand the relation between the mol. structures and the spectral properties of these dyes, theor. calculations were made using the Gaussian program. Key parameters related to absorption and emission spectra were reported and discussed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Absorption and fluorescence characteristics of some 2-alkyl- and 2-arylbenzoxazoles in different solvents and at various acid concentrations was written by Dey, Joy Krishna;Dogra, Sneh K.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical in 1990.Recommanded Product: 2,5-Dimethylbenzoxazole This article mentions the following:

Absorption and fluorescence spectral characteristics of some 2-alkyl- and 2-arylbenzoxazoles have been studied in different solvents and at various acid concentrations Dual fluorescence observed in the monocations of 2-alkylbenzoxazoles is due to π^* → π and charge transfer (CT) transitions, indicating the near degeneracy of excited single states. 2-Arylbenzoxazoles and the corresponding monocations exhibit only a single fluorescence band due to π^* → π transition. PK_a values for the monocation-neutral equilibrium in both S₀ and S₁ states of the mols. have been determined PPP method for all the mols. and CNDO/S method for 2-methyl-, and 2-phenylbenzoxazoles have been employed to calculate transition energies, transition polarization and charge densities at different atoms in the S₀ and S₁ states to substantiate exptl. data and, hence, to verify the applicability of the methods for heterocycles containing two hetero atoms. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Recommanded Product: 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Multicatalytic Beckmann rearrangement of 2-hydroxylarylketone oxime: Switchable synthesis of benzo[d]oxazoles and N-(2-hydroxylaryl)amides was written by Li, Zhen;Fang, Chengtao;Zheng, Yannan;Qiu, Guanyinsheng;Li, Xiaofang;Zhou, Hongwei. And the article was included in Tetrahedron Letters in 2018.Application of 5676-58-4 This article mentions the following:

A switchable synthesis route was developed for benzo[d]oxazole derivatives and (2-hydroxylaryl)benzamide from 2-hydroxylbenzeneketoxime using organomols. (BOP-Cl, and CNC) and Lewis acid cocatalyzed Beckmann rearrangement (BR) reaction. Further, this reaction was switched using different organocatalysts. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Application of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A cationic iridium-catalyzed C(sp³)-H silylation of 2-Alkyl-1,3-azoles at the α-position in the 2-alkyl group leading to 2-(1-Silylalkyl)-1,3-azoles was written by Hirano, Masaya;Fukumoto, Yoshiya;Matsubara, Nao;Chatani, Naoto. And the article was included in Chemistry Letters in 2018.Safety of 2,5-Dimethylbenzoxazole This article mentions the following:

The regioselective silylation of the α-C(sp³)-H bond in the 2-alkyl group in 2-alkyl-1,3-azole derivatives with hydrosilanes, catalyzed by the combination of (POCOP^tBu)IrHCl and NaBAr^F₄, leading to the production of 2-(1-silylalkyl)-1,3-azoles is described. The presence of 3,5-dimethylpyridine is required for the reaction to proceed. Although the reaction takes place both in the presence and absence of a hydrogen acceptor, the addition of an acceptor gave better results, in terms of the efficiency of the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Safety of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Safety of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem