Category: benzoxazole

Silica sulfuric acid catalyzed synthesis of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines under heterogeneous and solvent-free conditions was written by Mohammadpoor-Baltork, I.;Moghadam, M.;Tangestaninejad, S.;Mirkhani, V.;Zolfigol, M. A.;Hojati, S. F.. And the article was included in Journal of the Iranian Chemical Society in 2008.Reference of 5676-58-4 This article mentions the following:

A simple, rapid and efficient method for the preparation of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines from the reaction of orthoesters with o-aminophenols, o-phenylenediamine and 2-amino-3-hydroxypyridine in the presence of silica sulfuric acid under heterogeneous and solvent-free conditions is reported. The significant features of this method are short reaction times, high yields of the products, mild reaction conditions, solvent free reaction, cheapness, non-toxicity and reusability of the catalyst. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Reference of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Reference of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Isolation and identification of new components in the ether-soluble portion of cigarette smoke condensate was written by Newell, Marjorie P.;Heckman, Robert A.;Moates, Robert F.;Green, Charles R.;Best, Freddie W.;Schumacher, J. N.. And the article was included in Tobacco Science in 1978.Synthetic Route of C9H9NO This article mentions the following:

Smoke condensates from 4 different 85-mm nonfiltered, uncased cigarettes smoked under standard conditions were partitioned between ether and water. The ether-soluble material, ∼60% of the total, was chromatographed on silicic acid with increasingly polar solvents to give 7 fractions. Further separation of the fractions by liquid-liquid partitions, column chromatog., and semi-preparative gas-liquid chromatog. led to the isolation and identification of 643 compounds, of which 173 were not previously reported as smoke components. Identification of individual isolates was accomplished by comparison of their IR, NMR, MS, and gas-liquid chromatog. retention times with those of authentic samples. The new isolates include 13 acids, 13 lactones, 2 aldehydes, 56 ketones, 4 alcs., 15 phenols, 19 N heterocyclics, 15 aliphatic hydrocarbons, 33 cyclic hydrocarbons, and 3 miscellaneous compounds A number of these new compounds are known to be in tobacco leaf. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Synthetic Route of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Synthetic Route of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of triphenylamines via ligand-free selective ring-opening of benzoxazoles or benzothiazoles under superparamagnetic nanoparticle catalysis was written by Nguyen, Oanh T. K.;Nguyen, Long T.;Truong, Nhu K.;Nguyen, Viet D.;Nguyen, Anh T.;Le, Nhan T. H.;Le, Dung T.;Phan, Nam T. S.. And the article was included in RSC Advances in 2017.COA of Formula: C9H9NO This article mentions the following:

CuFe₂O₄ superparamagnetic nanoparticles were utilized as an effective recyclable heterogeneous catalyst for the synthesis of triphenylamines 2-HY-R-C₆H₃N(C₆H₄R¹)₂ (R = H, 5-Me; R¹ = H, 2-Me, 3-MeO, etc.; Y = S, O) via the ligand-free selective ring-opening reaction of benzoxazole, 2,5-dimethylbenzoxazole or benzothiazole with iodoarenes R¹C₆H₄X (X = I, Br, Cl). The nano CuFe₂O₄ demonstrated noticeably higher catalytic efficiency than a series of homogeneous catalysts and heterogeneous catalysts. It was possible to sep. the nano CuFe₂O₄ by using a magnet, and the recovered catalyst was reused many times while its activity could be maintained. This is the first example of heterogeneous catalysis for the transformation of benzoxazoles, and the transformation of benzothiazoles to triphenylamines has been reported. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium catalyzed C_sp²-H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals was written by Seth, Kapileswar;Nautiyal, Manesh;Purohit, Priyank;Parikh, Naisargee;Chakraborti, Asit K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Name: 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:

A novel strategy for direct aryl hydroxylation via Pd-catalyzed C_sp²-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Name: 2-(3-Bromophenyl)benzo[d]oxazole).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Name: 2-(3-Bromophenyl)benzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of diheteroarylacetylenes containing benzoxazole and pyridine groups was written by Liu, Jie;Zhuang, Jun-peng;Hao, Hai-jun;Zhang, Shu-guang;Niu, Jun-yu. And the article was included in Huaxue Shiji in 2015.Product Details of 5676-58-4 This article mentions the following:

Diheteroarylacetylenes containing benzoxazole and pryidine groups were synthesized from diheteroarylethenes in moderate yields by bromination with Br₂ in refluxing dichloromethane and then debromination with KOH-tBu in THF at room temperature Compared with the transition-metal-catalyzed methods, this procedure provided a metal-free, efficient and economical method with easily accessible starting materials form the synthesis of diheteroarylacetylenes. The UV and FL spectra were determined The photochem. determination showed that these diheteroarylethenes were photoinert to UV irradiation in organic solvent or in acidic aqueous solution In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Product Details of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Product Details of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Direct ortho-arylation of 2-arylbenzoxazoles via C-H activation was written by Yang, Fan;Wu, Yangjie;Zhu, Zhiwu;Zhang, Junli;Li, Yanan. And the article was included in Tetrahedron in 2008.Synthetic Route of C13H8BrNO This article mentions the following:

A new and highly regioselective arylation of 2-arylbenzoxazoles based on C-H activation has been developed. The results represent the first examples of palladium-catalyzed direct ortho-arylation of 2-arylbenzoxazoles and also provide a facile route for the synthesis of complicated structures containing arylated benzoxazoles moieties. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Synthetic Route of C13H8BrNO).

2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Synthetic Route of C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Carbon-Carbon Bond Cleavage of Diynes through the Hydroamination with Transition Metal Catalysts was written by Shimada, Tomohiro;Yamamoto, Yoshinori. And the article was included in Journal of the American Chemical Society in 2003.Recommanded Product: 5676-58-4 This article mentions the following:

The C-C bond cleavage of terminal and internal diynes takes place readily in the presence of catalytic amounts of Ru₃(CO)₁₂ or Pd(NO₃)₂ and of 2-aminophenol, giving the corresponding benzoxazoles and ketones in good to high yields. Thus, reaction of 2-H₂NC₆H₄OH with RCCCCH [R = hexyl, decyl, cyclohexyl, Me₃C, PhCH₂CH₂, (Me₂CH)₃SiO(CH₂)₄, Cl(CH₂)₃] in MeOH containing Ru₃(CO)₁₂ and NH₄PF₆ gave mixtures of 2-methylbenzoxazole and the C-2 substituted benzoxazoles I in 58-98% yields in addition to acetone and RCOMe. The substituted aminophenols II (R¹ = 4-NO₂, 4-Cl, 4-Me, 4-MeO, 5-NO₂, 5-Me, 3-Me) reacted similarly with 1,3-decadiyne to give methylbenzoxazoles III and hexylbenzoxazoles IV. The two different modes of bond cleavage in these reactions are cleavage of an alkyne C-C triple bond and cleavage of the C-C single bond between the two alkyne groups. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Recommanded Product: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Recommanded Product: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Structure and photochemical properties of r-1, c-2, t-3, t-4-1, 3-bis[2-(5-R-benzoxazolyl)]-2,4-di(4-R’-phenyl)cyclobutane was written by Zhang, Wen-Qin;Zhuang, Jun-Peng;Li, Chun-Bao;Sun, Hao;Yuan, Xue-Ning. And the article was included in Chinese Journal of Chemistry in 2001.Formula: C9H9NO This article mentions the following:

R-1,c-2,t-3,t-4-1,3-Bis[2-(5-R-benzoxazolyl)]-2,4-di(4-R’-phenyl)cyclobutane (I; R,R’ given: H, H; Me,H; Me,OMe) was synthesized with high stereo-selectivity by the photodimerization of trans-1-[2-(5-R-benzoxazolyl)]-2-(4-R’-phenyl)ethene (II: R, R’ as above )in sulfuric acid. The structures of I were identified by elemental anal., IR, UV, ¹H NMR, ¹³C NMR and MS. The mol. and crystal structure of I(R=Me,R’=MeO) has been determined by X-ray diffraction method. The crystals of (C₃₄H₃₀N₂O₄ · 0.5C₂H₅OH) are monoclinic, space group P2₁/n with cell dimensions of a = 1.5416(3), b = 0.5625(1), c = 1.7875(4) nm, β = 91.56 (3)°, V = 1.550(1) nm³, Z = 2. The structure shows that the mol. is centrosym., which indicates that the dimerization process is a head-to-tail fashion. The selectivity of the photodimerization of substrates was enhanced by using acidic solvent and the reaction speed would be decreased when electron donating group was introduced in the 4-position of the Ph group. That the photodimerization is not affected by the presence of oxygen as well as its high stereoselectivity demonstrated that the reaction proceeded through an excited single state. It was also found that under irradiation of short wavelength UV, these dimers underwent photolysis completely to reproduce its trans-monomers, and then the new formed species changed into their cis-isomers through trans-cis isomerization. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Long-Chained Acidic Ionic Liquids-Catalyzed Cyclization of 2-Substituted Aminoaromatics with β-Diketones: A Metal-Free Strategy to Construct Benzoazoles was written by Miao, Chengxia;Hou, Qin;Wen, Yating;Han, Feng;Li, Zhen;Yang, Lei;Xia, Chun-Gu. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.HPLC of Formula: 5676-58-4 This article mentions the following:

With long-chained acidic ionic liquids as catalysts, a metal-free, efficient, and universal strategy was developed to synthesize a series of benzoazole compounds through intermol. cyclization of 2-aminophenols/thiophenols/anilines with β-diketones. Compared with traditional ionic liquids, the long-chained ionic liquids with certain surfactivity exhibited better catalytic activities perhaps for micellar action and could be reused at least six times. A mechanism that involves condensation, nucleophilic addition, and C-C bond cleavage was proposed, and the imine compound was recognized as an important intermediate in the reaction. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4HPLC of Formula: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.HPLC of Formula: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst was written by Madabhushi, Sridhar;Chinthala, Narsaiah;Vangipuram, Venkata Sairam;Godala, Kondal Reddy;Jillella, Raveendra;Mallu, Kishore Kumar Reddy;Beeram, China Ramanaiah. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 5676-58-4 This article mentions the following:

An efficient 1-step method for the synthesis of amides and benzoxazoles directly from ketones and 2-hydroxyaryl ketones, resp., by the reaction with AcNHOH using H₂SO₄ as catalyst was described. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4SDS of cas: 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.SDS of cas: 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem