He, Li-Li’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2023-01-27 | CAS: 483-76-1

In vitro and in vivo antifungal activity of Cymbopogon citrates essential oils from different climate conditions against Botrytis cinerea. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Essential oils (EOs) are natural, volatile and aromatic substances extracted from some specific plants. EOs are the secondary metabolite of plants and usually varies with different plants and climate conditions, even in the same plant species but different climate conditions. The antifungal properties of EOs from medicinal as well as other edible plants have been recognized for very long time. Cymbopogon citratus oil, which is used as a food flavoring agent, possesses a broad spectrum of in vitro antifungal activities attributed to the high content of monoterpenoids such as ¦Á-Citral and ¦Â-Citral. In this study we focused on the changes of components of EOs in C. citratus growing in different climate conditions and their antifungal activities as well. The samples of C. citrates, fresh and dried, obtained from five different climate conditions in Southern and Southwestern China (Kunming, Jinghong, Fangchenggang, Zengcheng, Yuxi). The C. citrates EOs were extracted by the steam distillation method and analyzed by gas chromatog. coupled with mass spectrometry (GC-MS) and gas chromatog.-flame ionization detection (GC-FID). The results showed that the content of ¦Á-Citral was the highest in ten EOs. Fresh and dried C. citratus EOs accounted for 38.7% and 43.3% in Zengcheng, resp. However, fresh and dried C. citratus EOs accounted for 24.2% and 23.1% in Kunming. The effects of C. citratus EOs from different climate conditions against Botrytis cinerea were studied. All EOs had good inhibition against mycelial growth and spore germination of B. cinerea in vitro. At 15.63 mg/L, the inhibition of mycelial growth with the dried C. citrates EO from Zengcheng was significantly greater than that with the other EOs, with an inhibitory effect of 96.3%. It completely inhibited the mycelial growth of B. cinerea at 31.25 mg/L. Ten EOs also had good inhibitory effects on the rotten area of cherry tomatoes infected by B. cinerea in vivo. At 125 mg/L, the decay area of cherry tomatoes was reduced by more than 90%. The results indicated that the constituents in EOs of C. citrates are different from one growing place to another. The EOs of C. citrates may be considered as potential candidates to protect postharvest fruit from B. cinerea damage.

In vitro and in vivo antifungal activity of Cymbopogon citrates essential oils from different climate conditions against Botrytis cinerea. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Tsao, Nai-Wen’s team published research in Journal of Wood Science in 2022-12-31 | CAS: 483-76-1

Composition analysis of exudates produced by conifers grown in Taiwan and their antifungal activity. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Exudates are involved in the defense mechanism of trees; they could work against insects or microorganisms through a phys. or chem. system. The main components of exudates are terpenoids. This study identified the main compounds of exudates from 13 conifers of Taiwan using gas chromatogram-mass spectrometry (GC-MS) and spectroscopic anal. The results revealed that the main volatiles were ¦Á-pinene, ¦Â-ocimene, ¦Â-pinene, sabinene, and caryophyllene. On the other hand, the main nonvolatile compounds were diterpenoids, which were classified into three skeletons (abietane-, labdane-, and pimarane-types). Among these, abietane-type presented in Pinaceae and in most of Cupressaceae; labdane-type presented in Pinaceae and in all of Cupressaceae and Araucariaceae; pimarane-type existed in both Pinaceae and Cupressaceae. Furthermore, the epigenetics of conifers anal. results by GC-MS and heteronuclear single quantum coherence (HSQC) of NMR (NMR) fingerprints were similar to traditional taxonomy classification; it indicated that exudates chemotaxonomy by using GC-MS and HSQC profiling is a useful technol. to classify the conifers. Besides, the exudates of Pinus elliottii, Pinus taiwanensis, Calocedrus macrolepis and Chamaecyparis formosensis possessed the strong antifungal activity. For white-rot fungus, Trametes versicolor, Pinus morrisonicola, Chamaecyparis obtusa, and Araucaria heterophylla exhibited the higher antifungal index. For brown-rot fungus, Laetiporus sulfureus, Pinus elliottii, Pinus morrisonicola, and Chamaecyparis formosensis revealed a good antifungal activity.

Composition analysis of exudates produced by conifers grown in Taiwan and their antifungal activity. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shi, Yali’s team published research in Food Chemistry in 2022-11-15 | CAS: 483-76-1

Comprehensive investigation on non-volatile and volatile metabolites in four types of green teas obtained from the same tea cultivar of Longjing 43 (Camellia sinensis var. sinensis) using the widely targeted metabolomics. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

In this study, we produced roasted, baked, steamed, and sun-dried green tea products using the same batch of fresh tea leaves (FTL) of Longjing 43 (Camellia sinensis var. sinensis), and explored processing effects on the metabolic profiles of four types of green teas (FGTs) using the widely targeted metabolomics. Results showed that 146 differential metabolites including flavonoids, amino acids, lipids, and phenolic acids were screened among 1034 non-volatiles. In addition, nineteen differential metabolites were screened among 79 volatiles. Most of non-volatiles and volatiles metabolites changed notably in different manufacturing processes, whereas there were no significant differences (p>0.05) in the levels of total catechins between FGTs and FTL. The transformation of metabolites was the dominant trend during green tea processing. The results contribute to a better understanding of how the manufacturing process influences green tea quality, and provide useful information for the enrichment of tea biochem. theory.

Comprehensive investigation on non-volatile and volatile metabolites in four types of green teas obtained from the same tea cultivar of Longjing 43 (Camellia sinensis var. sinensis) using the widely targeted metabolomics. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zhou, Tao’s team published research in Journal of the American Chemical Society in 2021-05-12 | CAS: 4381-25-3

Efficient Synthesis of Sulfur-Stereogenic Sulfoximines via Ru(II)-Catalyzed Enantioselective C-H Functionalization Enabled by Chiral Carboxylic Acid. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

(S-Methylsulfonimidoyl)benzene (BD302898) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 83730-53-4 and 1621962-30-8.

A Ru(II)-catalyzed enantioselective C-H activation/annulation of sulfoximines with ¦Á-carbonyl sulfoxonium ylides using a novel class of chiral binaphthyl monocarboxylic acids as chiral ligands, which can be easily and modularly prepared from 1,1′-binaphthyl-2,2′-dicarboxylic acid to give benzo[e][1,2]thiazine 1-oxide derivatives I [R = i-Pr, 2-furyl, Ph, etc.; Ar = Ph, 3-ClC6H4, 4-F3CC6H4, 2-FC6H4, etc.] was described. A broad range of sulfur-stereogenic sulfoximines were prepared in high yields with excellent enantioselectivities (up to 99% yield and 99% ee) via desymmetrization, kinetic resolution, and parallel kinetic resolution Furthermore, the resolution products can be easily transformed to chiral sulfoxides and key intermediates for kinase inhibitors.

Efficient Synthesis of Sulfur-Stereogenic Sulfoximines via Ru(II)-Catalyzed Enantioselective C-H Functionalization Enabled by Chiral Carboxylic Acid. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zhang, Shiyu’s team published research in Toxicology and Applied Pharmacology in 2022-05-15 | CAS: 83730-53-4

DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

(2S)-2-Amino-4-(butylsulfonimidoyl)butanoic acid (BD136012) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 1621962-30-8.

8-Epidiosbulbin E acetate (EEA), a furan-containing diterpenoid lactone, is one of main component of Dioscorea bulbifera L.(DBL). It has been reported that EEA induces severe hepatotoxicity in mice and that its hepatotoxicity is associated with metabolic activation. The present study demonstrated that exposure to EEA (50, 100 or 200 ¦ÌM) induced DNA damage, including significant DNA fragmentation, increases of tail DNA and olive tail moment, H2AX phosphorylation and PARP-1 activation, in cultured mouse primary hepatocytes. Similar observation was obtained in mice administered EEA at 50, 100 or 200 mg/kg. Pre-treatment with 10 ¦ÌM ketoconazole (KTC), 200 ¦ÌM vitamin C (VC), or 200 ¦ÌM glutathione Et ester (GSH-OEt) reversed the over-production of reactive oxygen species (ROS) induced by EEA and attenuated susceptibility of hepatocytes to EEA-induced cytotoxicity and DNA damage in mouse primary hepatocytes. In contrast, pre-treatment with 1.0 mM L-buthionine sulfoximine (BSO) potentiated over-production of ROS, cytotoxicity and DNA damage induced by EEA. In summary, EEA induced DNA damage in cultured primary hepatocytes and the liver of mice. ROS, possibly along with DNA alkylation, participated in the observed DNA damage.

DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/50578-18-2.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Pham, Ty Viet’s team published research in Natural Product Communications in 2022-09-30 | CAS: 483-76-1

Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

This study analyzed the chem. composition and anti-osteoporosis activity of the n-hexane extract of Homalomena gigantea rhizome. Sixty compounds, representing 92.0% of the extract, were identified by gas chromatog.-mass spectrometry. Linalool (15.3%), oplopanone (9.8%), (¦¥)-¦Á-atlantone (5.6%), khusinol acetate (5.4%), bullatantriol (4.3%), and ¦Â-sitosterol (3.8%) were the main constituents. The anti-osteoporotic activity of the n-hexane extract was determined by measuring alk. phosphatase (ALP) activity, collagen content, and the mineralization of MC3T3-E1 cells. At concentrations of 4.0 and 20.0 ¦Ìg/mL, the n-hexane extract increased ALP activity by 8.2% and 23.7%, and increased collagen secretion by MC3T3-E1 cells by 114.9% and 112.4%, resp. At 4 ¦Ìg/mL, the extract significantly promoted the mineralization of MC3T3-E1 cells by as much as 133.2% compared to the neg. control. These results suggested that H. gigantea rhizome contains a natural anti-osteoporotic compound

Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

More, Satish G.’s team published research in Journal of Organic Chemistry in 2021-08-06 | CAS: 50578-18-2

Metal-Free, Acid-Catalyzed 1,6-Conjugate Addition of NH-Sulfoximines to para-Quinone Methides: Accessing to Diarylmethine Imino Sulfanone. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9

1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

An efficient and metal-free method for the construction of ¦Á-diarylmethine imino sulfanones e.g., I using acid-catalyzed 1,6-conjugate addition of sulfoximines e.g., II on para-quinine methides III (R = Ph, 4-fuloropheny, thiophen-2-yl, etc. R1 = Me, t-Bu) (p-QMs) was reported. This method showed broad functional group tolerance and a wide range of substrate scope with good to excellent yield. The excellent protocol exhibits mild reaction conditions with high atom economy. The practicability of the present method was supported by a Gram-scale reaction.

Metal-Free, Acid-Catalyzed 1,6-Conjugate Addition of NH-Sulfoximines to para-Quinone Methides: Accessing to Diarylmethine Imino Sulfanone. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Baranwal, Siddharth’s team published research in Asian Journal of Organic Chemistry in 2021-07-31 | CAS: 145026-07-9

Selenium Dioxide Promoted ¦Á-Keto N-Acylation of Sulfoximines Under Mild Reaction Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A practical method for the synthesis of ¦Á-ketoamides of sulfoximines I [R1 = Ph, 4-MeC6H4, Bn, etc.; R2 = Me, Et, Ph, etc.; R3 = H, 4-F, 2-Cl, etc.] was developed from NH-sulfoximines and acetophenones using selenium dioxide as an oxidant. The reactions proceeded under mild conditions in the absence of any additives and provided good to excellent yields of ¦Á-keto-N-acylsulfoximines. Moreover, the optimized condition was well-suited to the task of ¦Á-ketoacylation of sulfoximines with phenylacetaldehyde and arylacetylenes. ¦Á-Hydroxy N-acylsulfoximines were obtained in good yields from ¦Á-keto N-acylsulfoximines via reduction or Grignard reactions.

Selenium Dioxide Promoted ¦Á-Keto N-Acylation of Sulfoximines Under Mild Reaction Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chen, Lu’s team published research in Organic & Biomolecular Chemistry in 2022 | CAS: 145026-07-9

Rhodium(III)-catalyzed cascade C-H functionalization/annulation of sulfoximines with iodonium ylides for the synthesis of cyclohexanone-1,2-benzothiazines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A highly efficient Rh(III)-catalyzed cascade C-H activation/annulation of sulfoximines 2-R-3-R1-4-R2C6H2S(O)(=NH)R3 (R = H, Me, OMe, Cl, Br; R1 = H, Me, OMe, Br, NO2; R2 = H, F, CN, C(O)Me, etc.; R1R2 = -CH=CH-CH=CH-; R3 = Me, Et, Bn, etc.) with iodonium ylides I (n = 0, 1; R4 = H, Me, Ph; R5 = H, Me) under metal-oxidant-free conditions has been reported. The fused cyclohexanone-1,2-benzothiazine scaffolds II is readily achieved with a one-pot process in this reaction. This protocol exhibits good functional group tolerance and moderate to excellent yields. Addnl., the olefination of the target product II (n = 1; R = R1 = R2 = H; R3 = Me; R4 = R5 = H) illustrates the promising usefulness of this strategy.

Rhodium(III)-catalyzed cascade C-H functionalization/annulation of sulfoximines with iodonium ylides for the synthesis of cyclohexanone-1,2-benzothiazines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shahhoseini, Reza’s team published research in Biochemical Systematics and Ecology in 2022-10-31 | CAS: 483-76-1

Evaluation of phytochemical profiles and relationships of compounds in Lippia citriodora during multiple growth-exploitation phases. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

In the present study the variations of biomass, essential oil content and composition of lemon verbena (Lippia citriodora) during different growth-exploitation phases from 27th May 2020 to 8th June 2021 were investigated. The uniform rooted cuttings were planted in the greenhouse under natural light. The aerial parts of lemon verbena at flowering stage were harvested at six times included 27th May (H1), 29th August (H2), 4th Nov. (H3), 17th Jan. (H4), 27th March (H5), and 8th June (H6). Hydro distillated essential oils were analyzed by using GC-FID and GC/MS techniques to determine the essential oil profile. Results showed a considerable variation in plant biomass, essential oil quantity and quality at different harvesting times. Plant biomass increased by 66.83% up to fourth harvesting time (H4) then decreased. During the studied harvesting frequencies the essential oil content of L. citriodora showed a sinusoidal trend. The highest essential oil content (0.858% v/w) and yield (17.95 L ha-1) were obtained at third harvesting time (H3) and in the followed harvesting times their contents were decreased. The observed changes in the essential oil composition of L. citriodora during different harvesting times were due to the relative proportions of constituents and the presence of new constituents. In the all essential oil samples, oxygenated monoterpenes represented by geranial (25.42-30.11%) and neral (19.81-24.19%) were the predominant compounds The highest ratio of monoterpenes to sesquiterpenes compounds (¡Ö5:1) was recorded in collected plants at third harvesting time.

Evaluation of phytochemical profiles and relationships of compounds in Lippia citriodora during multiple growth-exploitation phases. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem