Category: benzoxazole

The chromogenic properties of 2-(2-carbomethoxy-3,4-dichloro-6-hydroxyphenyl)benzoxazole (1) were studied. Solvatochromism of 1 was observed at keto-enol equilibrium due to the ground state intramolecular proton transfer (GSIPT). It was found that solvents with a good hydrogen bond acceptor (beta) ability were able to stabilise the keto form of 1. The excited-state intra molecular proton transfer (ESIPT) in molecules of 1 resulted in intense fluorescence with an anomalous Stokes shift of up to 8493 cm 1 and quantum yields of 0.08-0.19. The keto-form of 1 exhibits negative T-type photochromism with a thermally reversible photoconversion to the enol form. The complexes of ligand 1 with Zn(II) and Cd(II) were synthesised. According to X-ray structural analysis, the zinc complex is the neutral complex, which is formed by two oxazole-N and two phenol O donors of ligand 1 which crystallise in a centrosymmetric group with the zinc ion located on the inversion centres. The synthesised complexes possess effective blue fluorescence and resistance to photodegradation.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New research progress on 165534-43-0 in 2021.Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. 165534-43-0, Name is Diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl) phosphate, molecular formula is C11H14N3O5P, belongs to benzoxazole compound. In a document, author is Omar, A. Mohsen M. E., Electric Literature of 165534-43-0.

New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d and 11c eliciting the highest activity against MCF-7 cells were further assayed for their cytotoxic activities against A431 and HCC827 cancer cells in addition to their in vitro inhibition of wild and mutated epidermal growth factor receptor (EGFR) enzymes. Compound 11c was the most active against A431 cells and it displayed a potent inhibition of EGFR(WT) while compounds 4b and 4d elicited higher potencies than erlotinib against mutated EGFR(L858R). Compounds 4a, 6c and 8a showed the most potent cytotoxic activity against MDA-MB-231 cancer cells where compounds 4a and 6c were slightly less potent aromatase (ARO) inhibitors than letrozole. MCF-7 cells treated with compounds 4b, 4d, 11c and MDA-MB-231 cells treated with compounds 4a, 6c and 8a showed remarkable over-expression of caspase-9 protein level and elicited pre G1 apoptosis and cell cycle arrest at G2/M phase in addition to high annexin V binding affinity indicating significant apoptosis. Chemo-informatic and docking properties were also predicted. Docking results revealed that docked compounds displayed binding modes with EGFR and ARO enzymes comparable to that of the reference ligands. The benzoxazole derivatives 11c and 6c possessing amide and dithiocarbamate moieties respectively were found to be potent apoptosis-inducing anti-breast cancer agents with acceptable physicochemical properties. They exert their activity via inhibition of EGFR and ARO enzymes respectively.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry built the modern world, from the materials that make up the everyday objects around us, the batteries in our devices and cleaning products that help to maintain sanitation. 1235481-90-9, Name is P7C3-A20, molecular formula is C22H19Br2FN2O, belongs to benzoxazole compound. In a document, author is Omar, A. Mohsen M. E., Recommanded Product: P7C3-A20.

New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d and 11c eliciting the highest activity against MCF-7 cells were further assayed for their cytotoxic activities against A431 and HCC827 cancer cells in addition to their in vitro inhibition of wild and mutated epidermal growth factor receptor (EGFR) enzymes. Compound 11c was the most active against A431 cells and it displayed a potent inhibition of EGFR(WT) while compounds 4b and 4d elicited higher potencies than erlotinib against mutated EGFR(L858R). Compounds 4a, 6c and 8a showed the most potent cytotoxic activity against MDA-MB-231 cancer cells where compounds 4a and 6c were slightly less potent aromatase (ARO) inhibitors than letrozole. MCF-7 cells treated with compounds 4b, 4d, 11c and MDA-MB-231 cells treated with compounds 4a, 6c and 8a showed remarkable over-expression of caspase-9 protein level and elicited pre G1 apoptosis and cell cycle arrest at G2/M phase in addition to high annexin V binding affinity indicating significant apoptosis. Chemo-informatic and docking properties were also predicted. Docking results revealed that docked compounds displayed binding modes with EGFR and ARO enzymes comparable to that of the reference ligands. The benzoxazole derivatives 11c and 6c possessing amide and dithiocarbamate moieties respectively were found to be potent apoptosis-inducing anti-breast cancer agents with acceptable physicochemical properties. They exert their activity via inhibition of EGFR and ARO enzymes respectively.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The data presented in this specified data article comprise of various characterization such as: structural, thermal, elemental etc. to understand the novel structure and specific properties of the bio-based plastic as described in the main research article High-performance poly (benzoxazole/benzimidazole)bio-based plastics with ultra-low dielectric constant from 3-amino-4-hydroxybenzoic acid [1]. The data of H-1 NMR spectra of two monomers and their HCl salt formation required for polymerization, FT-IR spectra of polymer formation before and after thermal ring-closing and additionally supported by the thermogravimetric plots where mass loss due to water is observed around 400 degrees C (thermal ring closing temperature). Solvent plays effective role to change dielectric properties significantly, complete removal of the remaining solvents was confirmed by X-ray photoelectron spectroscopy (XPS) technique. Wide-angle XRD dataset was presented here to make an idea about degree of crystallinity of the prepared polymers. (C) 2019 The Authors. Published by Elsevier Inc.

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Benzoxazole – Wikipedia,
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Why do aromatic interactions matter? In this blog, let’s explore why it’s so important to understand aromatic interactions using C7H7FN2O3 as examples. Electric Literature of 1075705-01-9

A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole, triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl) ethylideneamino]-2-thioxoimidazolidin-4-one 1 as the key starting material. The key material 1 also, reacted with an acetic anhydride, aromatic aldehydes, secondary amines, formaldehyde and triethyl orthoformate to give the corresponding acetyl, chalcone, Mannich bases and ethoxymethylene derivatives, respectively. The structures of the novel compounds were confirmed by spectral data and elemental analysis. The cytotoxic activity of all synthesized compounds was assessed in vitro against human hepatocellular cancer cell line (HePG-2) and breast carcinoma cell line (MCF-7). The bioassay results revealed that compound 14 has the best activity against HePG-2 cell line (IC50 = 2.33 mu g/mL), while compound 5 has the best activity against MCF-7 cell line (IC50 = 3.98 mu g/mL).

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New Advances in Chemical Research in 2021. Catalysts are in the same phase as the reactants. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 10465-78-8, Name is N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide, molecular formula is C6H12N4O2, belongs to benzoxazole compound. In a document, author is Xia, Lixian, Quality Control of N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide.

Reaction of 1,4-bis(benzo[d]oxazol-2-yl)butane (BBO) with [Ag(CH3CN)(4)(ClO4)] afforded a new binuclear silver(I) complex, with composition [Ag-2(BBO)(2)(ClO4)(2)], characterized by elemental analysis, UV/Vis and IR spectroscopy, and single-crystal X-ray diffraction. The results show that the Ag(I) complex consists of a centrosymmetric dimetallacyclic structure assembled from two Ag(I) atoms and two bridging BBO ligands. The coordination environment of silver(I) complex can be described as distorted trigonal planar, with one oxygen atom from a perchlorate anion and two nitrogen atoms from two BBO ligands. The luminescence properties of the ligand and the Ag(I) complex were studied in the solid state. The emission peaks of the Ag(I) complex are attributed to ligand-centered transitions. There is no effect of the complexation except for a partial quenching. The cyclic voltammograms of the Ag(I) complex indicated an irreversible Ag+/Ag couple.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A couple of challenges comes to mind: improving temperature dependence of relative stabilities of polymorphs would help in identifying enantiotropic relationships. 76-37-9, Name is 2,2,3,3-Tetrafluoropropan-1-ol, molecular formula is C3H4F4O, belongs to benzoxazole compound. In a document, author is Maeno, Nobuhisa, Reference of 76-37-9.

Objective The purpose of this study was to investigate whether beta-amyloid (A beta) deposition was associated with local atrophy of corresponding areas in the brain. Methods [11C]2-[2-(2-Dimethylaminothiazol-5-yl) ethenyl-6-[2-(fluoro)ethoxy]benzoxazole (BF-227)-PET, MRI and neuropsychological tests were carried out on 56 subjects, out of which 21 were patients with Alzheimer’s disease (AD), 20 were patients with mild cognitive impairment (MCI) and 15 were normal controls (NC). The BF-227 uptake in each local brain region was set up with automated anatomical labeling atlas using Wake Forest University PickAtlas software and local standardized uptake value ratios of BF-227 were calculated as the average value of right and left using the MRIcron software. Results Group comparisons of A beta deposition as determined by BF-227 uptake using PET imaging showed no significant differences between MCI and AD. A beta deposition was significantly higher in MCI and AD than in NC. The correlation analysis between local A beta deposition and gray matter atrophy showed that in AD, the A beta deposition in the inferior temporal gyrus was strongly related to the gray matter atrophy in this region. On the contrary, the A beta deposition in the precuneus was associated with the atrophy in the right occipital-temporal region. In the NC, the A beta deposition in the inferior temporal gyrus was associated with the atrophy in the precuneus. Conclusion In the AD, the relationship between the A beta deposition and local atrophy is area-dependent. In NC, A beta deposition in the inferior temporal gyrus correlated to the atrophy in the precuneus.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis.348-54-9, Name is 2-Fluoroaniline, molecular formula is C6H6FN. In an article, author is Singh, Mala,once mentioned of 348-54-9, Recommanded Product: 348-54-9.

Cu-catalyzed Ullmann coupling was performed for the facile synthesis of diverse benzoxazoles and benzothiazoles in the presence of 1-(hydroxymethyl)-1H-benzotriazole as ligand and K2CO3 as base in anhydrous DMF at 120 degrees C.

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Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. Related Products of 1714-29-0, Name is 1-Bromopyrene, molecular formula is C16H9Br, molecular weight is 281.15, category is benzoxazole. Now introduce a scientific discovery about this category.

Membrane technology operating in highly concentrated solutions is essential in pressure retarded osmosis (PRO) applications to compete with other renewable energy technologies. Herein, we fabricated highly porous and robust electrospun membranes (ESMs) using a poly(benzoxazole-co-imide) (PBO) polymer. For the first time in osmotic-driven systems, novel one-step direct fluorination was adopted to increase hydrophilicity of the ESM. Direct fluorination increased the total surface energy of the ESM by boosting polar surface energy parameter, which eventually affected the formation of ‘ridge & valley’-like thin film composite membrane (PBO-TFC-F5) through interfacial polymerization of the fluorinated ESM. As a result, PBO-TFC-F5 achieved an unprecedented power density of 87.2 W m(-2) using 3 M NaClaq as a draw solution at 27 bar. When PBO-TFC-F5 was used for osmotic heat engine (OHE), it showed a power generation cost of only 203 $center dot MWh(-1), which was less than half the cost observed using commercial membranes. This robust, porous, and high performance PBO-TFC-F5 opens up new possibilities in membrane-based power generation systems.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In this document, 1-(Hydroxymethyl)-1H-benzotriazole: An Efficient Ligand for Copper-Catalyzed Ullmann-Type Coupling Reaction Leading to Expeditious Synthesis of Diverse Benzoxazoles and Benzothiazoles. Category: benzoxazole.

Although compounds with a 2-(2-arylphenyl) benzoxazole motif are biologically important, there are only a few methods for synthesizing them. Herein, we report an efficient method for synthesis of such compounds by means of cobalt-catalyzed C-H/C-H cross-coupling reactions. This method has a broad substrate scope and good tolerance for sensitive functional groups. In addition, we demonstrate that introducing a heteroarene moiety to biphenyl compounds enhanced their antifungal activity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about C6H4F2. Category: benzoxazole.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem