Category: benzoxazole

New discoveries in chemical research and development in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 51-67-2, Name is Tyramine, molecular formula is C8H11NO. In an article, author is Pattarawarapan, Mookda,once mentioned of 51-67-2, Recommanded Product: Tyramine.

The unprecedented reaction of tertiary amines with 2(3H)-benzoxazolones has been investigated. In the presence of the Ph3P-I-2 reagent system, the reaction of both acyclic and cyclic aliphatic tertiary amines led to the formation of 2-N,N-dialkylaminobenzoxazoles with the selective cleavage of an alkyl group. Especially, N-(2-iodoethyl)piperazinyl derivatives were rapidly produced in good yields when using DABCO as the nitrogen source. Only in the cases when the nucleophilicity of the substrates exceeds that of the amine, competitive self -condensation of benzoxazolones then proceeds preferentially. P-31{H-1}-NMR study suggested the involvement of an aryloxyphosphonium intermediate and/or possibly 2-iodobenzoxazole which activates the C-2 position of benzoxazolones toward nucleophilic aromatic substitution.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis.372-38-3, Name is 1,3,5-Trifluorobenzene, molecular formula is C6H3F3. In an article, author is Sahoo, Kanchanbala,once mentioned of 372-38-3, Recommanded Product: 1,3,5-Trifluorobenzene.

A Pd-catalyzed aerobic approach to access C4-aryl benzoxazoles by tandem C-H ortho-arylation and acid-mediated annulation of 2-amidophenol has been presented. The directing potential of the -NHCOR group over the -OH group was exploited for selective arylation adjacent to the amide group. Deuterium labeling experiments suggest that palladation predominantly occurs adjacent to the -NHCOR group and is the key step during benzoxazole formation. One-pot hydrolysis of the resulting C4-arylated benzoxazole was also accomplished to access structurally challenging 3-aryl aminophenols for further applications.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New research progress on 352-34-1 in 2021.Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. 352-34-1, Name is 1-Fluoro-4-iodobenzene, molecular formula is , belongs to benzoxazole compound. In a document, author is Li, Zhengyu, Category: benzoxazole.

A one-pot strategy for the diversified synthesis of 3-difluoromethyl benzoxazole-2-thiones is reported. The reaction of 2-aminophenol, sodium chlorodifluoroacetate, and elemental sulfur in the presence of NaOt-Bu gives exclusively 3-difluoromethyl benzoxazole-2-thiones in good yield (up to 98%). The mechanism of this reaction presumably involves first cyclization of 2-aminophenols with thiocarbonyl fluoride, followed by N-difluoromethylation with difluorocarbene. The developed synthetic procedures are versatile, robust, and easily scalable for the synthesis of 3-difluoromethyl benzoxazole-2-thione derivatives, some of which have shown insecticidal activities.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. In an article, author is Zhou, Yan, once mentioned the application of 129-64-6, COA of Formula: https://www.ambeed.com/products/129-64-6.html, Name is (3aR,4S,7R,7aS)-rel-3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione, molecular formula is C9H8O3, molecular weight is 164.158, category is benzoxazole. Now introduce a scientific discovery about this category.

As a GSK-3 beta inhibitor reported by our group, K313 is a novel benzoxazole derivative and displays anti-inflammatory properties in RAW264.7 macrophages without cytotoxicity. The activity of GSK-3 beta affects the differentiation and maturation of bone marrow-derived dendritic cells (DCs). This study aims to investigate whether K313 can be used to induce regulatory/tolerogenic dendritic cells (DCregs), and the therapeutic effects of DCregs induced by K313 in the autoimmune model of experimental autoimmune encephalitis (EAE). The results show that compared with LPS stimulated mature DCs, K313-treated bone marrow-derived DCs display obvious tolerogenic characteristics with decreased expression of co-stimulatory molecules, downregulated secretions of pro-inflammatory cytokines and unregulated secretion of anti-inflammatory cytokine IL-10. The above characteristics conform to the typical phenotypes of DCregs. Moreover, K313-modified DCregs inhibit antigen-specific T cell responses in vitro. Furthermore, by adoptive transfer, K313 modified DCregs to the EAE mice, and the development of disease was ameliorated to some extent. In addition, treatment with K313-modified DCregs also significantly reduced the percentages of splenetic Th1 and Th17 cells and increased the percentage of regulatory T cells in EAE mice. In conclusion, K313-modified DCregs show anti-inflammatory properties in vitro and have a significant positive effect on the EAE disease in vivo. Our data indicate that K313-induced DCregs pulsed with auto-antigen might have potential use as a therapeutic approach for autoimmune inflammation of the central nervous system.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Research speed reading in 2021. Catalysts allow a reaction to proceed that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 590-67-0, Name is 1-Methylcyclohexanol, molecular formula is , belongs to benzoxazole compound. In a document, author is Ferreira, Rosa Cristina M., COA of Formula: https://www.ambeed.com/products/590-67-0.html.

A family of novel thienylbenzoxazol-5-yl-L-alanines, consisting of an alanine core bearing a benzoxazole at the side chain with a thiophene ring at position 2, substituted with different (hetero)aryl substituents, was synthesised to study the tuning of the photophysical and chemosensory properties of the resulting compounds. These novel heterocyclic alanines 3a-f and a series of structurally related bis-thienylbenzoxazolyl-alanines 3g-j were evaluated for the first time in the recognition of selected metal cations with environmental, medicinal and analytical interest such as Co2+, Cu2+, Zn2+ and Ni2+, in acetonitrile solution, with the heterocycles at the side chain acting simultaneously as the coordinating and reporting units, via fluorescence changes. This behaviour can be explained by the involvement of the electron donor heteroatoms in the recognition event, through complexation of the metal cations. The spectrofluorimetric titrations showed that thienylbenzoxazolyl-alanines 3a-j and 4a,b were non-selective fluorimetric chemosensors for the above-mentioned cations, with the best results being obtained for the interaction of Cu2+ with bis-alanine 3j and deprotected alanines 4a,b. The encouraging photophysical and metal ion sensing properties of these thienylbenzoxazolyl-alanines suggest that they can be used to obtain bioinspired fluorescent reporters for metal ion such as peptides/proteins with chemosensory/probing ability.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 6825-20-3, Name is 3,6-Dibromo-9H-carbazole, molecular formula is C12H7Br2N. In an article, author is Vlasov, S. V.,once mentioned of 6825-20-3, Safety of 3,6-Dibromo-9H-carbazole.

An approach to the synthesis of new 6-(1,3-benzoxazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-ones and their 4-thioanalogs was developed. Some of the synthesized compounds exhibited antimicrobial activity against strains of Bacillus subtilis bacteria and Candida albicans fungi.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New research progress on 6674-22-2 in 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 6674-22-2, Name is 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine, molecular formula is , belongs to benzoxazole compound. In a document, author is Kaloglu, Murat, Recommanded Product: 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine.

Herein, we report that a series of novel palladium(II)-NHC complexes (NHC=N-heterocyclic carbene) were synthesized. The structures of all novel complexes were characterized by H-1 NMR, C-13 NMR, FT-IR spectroscopy and elemental analysis techniques. These palladium(II)-NHC complexes were tested as efficient catalysts in the direct CH bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 degrees C for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2-arylbenzoxazoles and 2-arylbenzothiazoles in acceptable to high yields.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 423-39-2, Name is Perfluorobutyliodide, molecular formula is C4F9I. In an article, author is Yang, Rui,once mentioned of 423-39-2, Application of 423-39-2.

In this study, an amide functionalized bis-benzoxazine (AI-al) has been synthesized using allylamine,ortho-amide functional bis-phenol and paraformaldehyde as raw materials via Mannich condensation. This newly obtained benzoxazine has been used to react with polydimethylsiloxane (PDMS) through hydrosilylation to form poly(benzoxazine-co-amide-co-siloxane) (AI-al-PDMS) featuring siloxane, amide and benzoxazine as repeating units. The chemical structures of both oxazine ring-containing monomer and copolymer are confirmed by NMR and FT-IR spectroscopies. Besides, the thermally activated polymerization behaviors of AI-al and AI-al-PDMS are investigated by DSC, and the subsequent conversion of benzoxazole formation is studied by in situ FT-IR. Moreover, dynamic mechanical analysis and thermogravimetric analysis are used to determine the thermal properties of the cross-linked polymers. The resulting cross-linked poly(benzoxazole-co-siloxane) derived from AI-al-PDMS shows excellent thermal stability (noT(g)can be observed before 400 degrees C; Td5 of 393 degrees C) and low dielectric constants (2.52-2.13 in the frequency range of 1 Hz to 1 MHz), evidencing its great potential applications in electronic packing, aerospace, and other high-performance fields.

Application of 423-39-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 423-39-2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Research speed reading in 2021. Catalysts allow a reaction to proceed that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 129-64-6, Name is (3aR,4S,7R,7aS)-rel-3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione, molecular formula is , belongs to benzoxazole compound. In a document, author is Benzai, A., Recommanded Product: 129-64-6.

Three functional, N-donorbidentates ligands, L1: 2-(pyridin-2-yl) benzoxazole L2: 2-(quinolin-2-yl) benzoxazole and L3: 2-(4-(trifluoromethyl) pyridin-2-yl) benzoxazole have been examined for their catalytic oxidative activities. The dioxygen complexes of Cu(II) were generated in situ by stirring copper salts and bidentates ligands derivated from benzoxazole. It has been found that these compounds are very efficient to give oquinone. The nature of the ligands, the counter anion copper (II) salts and solvent have been investigated. These three parameters have an important effect on the oxidation reaction rate.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New Advances in Chemical Research in 2021.The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 165534-43-0, Name is Diethyl (4-oxobenzo[d][1,2,3]triazin-3(4H)-yl) phosphate, molecular formula is , belongs to benzoxazole compound. In a document, author is Kuhlmann, Lisa, Synthetic Route of 165534-43-0.

A series of ten heteroleptic and homoleptic mononuclear Zr(iv) and Hf(iv) complexes bearing differently substituted phenoxy-benzoxazole ligands was synthesised. The complexes were characterised by H-1 and C-13{H-1} NMR spectroscopy as well as by elemental analyses and X-ray diffraction experiments. The molecular structures show octahedral or tetragonal-antiprismatic coordination motifs at the metal atom. The crystal packing patterns depend on the substitution of the ligands. The intermolecular interactions in the solid state are governed by weak – interactions, and are also dependent on the ligand structure. Photo-physical investigations reveal that all ten complexes show a ligand-centered fluorescence with emission maxima in the blue region of the electromagnetic spectrum.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem