Category: benzoxazole

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 405-50-5, Name is 2-(4-Fluorophenyl)acetic acid, molecular formula is C8H7FO2. In an article, author is Bucki, Adam,once mentioned of 405-50-5, Quality Control of 2-(4-Fluorophenyl)acetic acid.

Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD)

Patients suffering from dementia experience cognitive deficits and 90% of them show non-cognitive behavioral and psychological symptoms of dementia (BPSD). The spectrum of BPSD includes agitation, depression, anxiety and psychosis. Antipsychotics, e.g. quetiapine, have been commonly used off-label to control the burdensome symptoms, though they cause serious side effects and further cognitive impairment. Therefore, the development of targeted therapy for BPSD, suitable for elderly patients, remains relevant. A multitarget-directed ligand, acting on serotonin 5-HT2A and dopamine D-2 receptors (R) and thus exerting anti-aggressive and antipsychotic activity, as well as on 5-HT(6)Rs and 5-HT(7)Rs ( potential procognitive, antidepressant and anxiolytic activity), poses a promising strategy for the treatment of BPSD. Antitargeting muscarinic M3R and hERG channel is expected to reduce the risk of side effects. We obtained a series of stereoisomeric compounds by combining 6-fluoro-1,2-benzoxazole moiety and arylsulfonamide fragment through pyrrolidin-1-yl-propyl linker. N-[(3R)-1-[3-(6-fluoro-1,2-benzoxazol-3-yl)propyl]pyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide showed a substantial affinity for the targets of interest (pK(i) = 8.32-9.35) and no significant interaction with the antitargets. Functional studies revealed its antagonist efficacy (pK(B) = 7.41-9.03). The lead compound showed a promising profile of antipsychotic-like activity in amphetamine- and MK-801-induced hyperlocomotion (MED = 2.5 mg/kg), antidepressant-like, as well as anxiolytic-like activity in mice (MED = 0.312 and 1.25 mg/kg in the forced swim and four-plate tests, respectively). Notably, the novel compound didn’t affect spontaneous locomotor activity, nor induced catalepsy or memory deficits (step-through passive avoidance test) in therapeutically relevant doses, which proved its benign safety profile. The overall pharmacological characteristics of the lead compound outperformed the reference drug quetiapine, making it a promising option for evaluation in the treatment of BPSD. (c) 2020 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 348-54-9, Name is 2-Fluoroaniline, SMILES is NC1=CC=CC=C1F, in an article , author is Nag, Aniruddha, once mentioned of 348-54-9, Formula: C6H6FN.

Dataset of various characterizations for novel bio-based plastic poly(benzoxazole-co-benzimidazole) with ultra-low dielectric constant

The data presented in this specified data article comprise of various characterization such as: structural, thermal, elemental etc. to understand the novel structure and specific properties of the bio-based plastic as described in the main research article High-performance poly (benzoxazole/benzimidazole)bio-based plastics with ultra-low dielectric constant from 3-amino-4-hydroxybenzoic acid [1]. The data of H-1 NMR spectra of two monomers and their HCl salt formation required for polymerization, FT-IR spectra of polymer formation before and after thermal ring-closing and additionally supported by the thermogravimetric plots where mass loss due to water is observed around 400 degrees C (thermal ring closing temperature). Solvent plays effective role to change dielectric properties significantly, complete removal of the remaining solvents was confirmed by X-ray photoelectron spectroscopy (XPS) technique. Wide-angle XRD dataset was presented here to make an idea about degree of crystallinity of the prepared polymers. (C) 2019 The Authors. Published by Elsevier Inc.

Interested yet? Read on for other articles about 348-54-9, you can contact me at any time and look forward to more communication. Formula: C6H6FN.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ge, Bailu, once mentioned the application of 423-39-2, Name is Perfluorobutyliodide, molecular formula is C4F9I, molecular weight is 345.9329, MDL number is MFCD00001062, category is benzoxazole. Now introduce a scientific discovery about this category, COA of Formula: C4F9I.

Acid-promoted cleavage of the C-C double bond of N-(2-Hydroxylphenyl)enaminones for the synthesis of benzoxazoles

An acid-mediated selective cleavage of C-C double bond of N-(2-hydroxylphenyl)enaminones with formation a new C-O bond for the synthesis of 2-substituted benzoxazoles has been developed. This protocol proceeds under transition metal- and oxidant-free conditions with broad functional group tolerance. The oxidative cleavage of C-C double bond of N-(2-hydroxylphenyl)enaminone is also realized using NCS or NFSI as oxidants with release of 2,2-dihalogen-acetophenone fragments. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 5535-48-8, Name is (Vinylsulfonyl)benzene, SMILES is O=S(C1=CC=CC=C1)(C=C)=O, belongs to benzoxazole compound. In a document, author is Angajala, Gangadhara, introduce the new discover, COA of Formula: C8H8O2S.

Microwave assisted amberlite-IRA-402 (OH) ion exchange resin catalyzed synthesis of new benzoxazole scaffolds derived from antiinflammatory drugs aceclofenac and mefenamic acid as potential therapeutic agents for inflammation

An efficient microwave assisted synthesis of 2-substituted benzoxazole derivatives from antiinflammatory drugs aceclofenac and mefenamic acid using amberlite-IRA-402 (OH) ion exchange resin as a base catalyst were reported. The synthesized compounds were purified and characterized by H-1 NMR, C-13 NMR and Mass spectroscopy. In silico molecular docking studies were carried out to predict the binding affinity of the synthesized benzoxazole derivatives with COX-2 protein. Molecular Docking analysis showed that compounds 4 and 7 possess excellent binding affinity towards COX-2 with a docking score of -11.6 and -10.4 kcaL/mol respectively. The results obtained from in vitro antiinflammatory studies towards membrane stabilization and proteinase inhibitory activities showed that the synthesized benzoxazole compounds 4 and 7 possess better efficacy when compared to that of standards aceclofenac and etodolac with a percentage inhibition of 74.22 +/- 0.15, 70.64 +/- 0.24 for membrane stabilization and 75.19 +/- 0.12, 71.80 +/- 0.49 for proteinase enzyme assay at 100 mu moL/L. The synthesized compounds 4 and 7 were also evaluated for antioxidant activity which showed good inhibition (70.16 +/- 0.31 and 68.25 +/- 0.49) at 100 mu moL/L which was on Par to that of standard ascorbic acid. (C) 2019 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 5535-48-8 is helpful to your research. COA of Formula: C8H8O2S.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 2343-89-7, Name is Methyl 2-fluoroacrylate, molecular formula is C4H5FO2, belongs to benzoxazole compound, is a common compound. In a patnet, author is Wang, Cong, once mentioned the new application about 2343-89-7, Name: Methyl 2-fluoroacrylate.

(Phosphinito)aryl benzimidazole PCN pincer palladium(II) complexes: Synthesis, characterization and catalytic activity in C-H arylation of azoles with aryl iodides

The PCN pincer Pd(II) complexes 4a-c with (phosphinito)aryl benzimidazole ligands were conveniently synthesized by one-pot phosphorylation/palladation reaction of a (2-benzimidazolyl)-containing m-phenol derivative 3. The three complexes were well characterized by spectroscopic methods, elemental analysis and their molecular structures were further determined by X-ray single-crystal diffraction. The Pd(II) center in each complex adopts a typical distorted-square-planar geometry. With a catalyst loading of 0.25-0.5 mol%, complex 4a could effectively catalyze C-H arylation of benzothiazole, benzoxazole and thiazole with various aryl iodides in the presence of Cul as a cocatalyst. (C) 2017 Elsevier Ltd. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 2343-89-7. The above is the message from the blog manager. Name: Methyl 2-fluoroacrylate.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

104-88-1, Name is 4-Chlorobenzaldehyde, molecular formula is C7H5ClO, belongs to benzoxazole compound, is a common compound. In a patnet, author is Zhong, Wenying, once mentioned the new application about 104-88-1, Recommanded Product: 4-Chlorobenzaldehyde.

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells

Benzoxazole derivative K313 has previously been reported to possess anti-inflammatory effects in lipopolysaccharide-induced RAW264.7 macrophages. To date, there have been no related reports on the anticancer effects of K313. In this study, we found that K313 reduced the viability of human B-cell leukemia (Nalm-6) and lymphoma (Daudi) cells in a dose-dependent manner without affecting healthy peripheral blood mononuclear cells (PBMCs) and induced moderate cell cycle arrest at the G0/G1 phase. Meanwhile, K313 mediated cell apoptosis, which was accompanied by the activation of caspase-9, caspase-3, and poly ADP-ribose polymerase (PARP). Furthermore, cells treated with K313 showed a significant decrease in mitochondrial membrane potential (MMP), which may have been caused by the caspase-8-mediated cleavage of Bid, as detected by Western blot analysis. We also found that K313 led to the downregulation of p-p70S6K protein, which plays an important role in cell survival and cell cycle progression. In addition, treatment of these cells with K313 blocked autophagic flux, as reflected in the accumulation of LC3-II and p62 protein levels in a dose- and time-dependent manner. In conclusion, K313 decreases cell viability without affecting normal healthy PBMCs, induces cell cycle arrest and apoptosis, reduces p-p70S6K protein levels, and mediates strong autophagy inhibition. Therefore, K313 and its derivatives could be developed as potential anticancer drugs or autophagy blockers in the future.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Reference of 76-37-9, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 76-37-9, Name is 2,2,3,3-Tetrafluoropropan-1-ol, SMILES is OCC(F)(F)C(F)F, belongs to benzoxazole compound. In a article, author is Zolottsev, V. A., introduce new discover of the category.

Synthesis of nitrogen-containing derivatives of 17(20)-pregnenoic, 17 beta-hydroxypregnanoic, and 17 alpha-hydroxypregnanoic acids as new potential antiandrogens

A general scheme for the synthesis of oxazoline and benzoxazole derivatives of [17(20)E]-21-norpregnene differing in the structure of the steroid moiety as well as amides of 17 beta-hydroxy-3-oxopregn-4-en-21-oic and 17 alpha-hydroxy-3-oxopregn-4-en-21-oic acids was developed. The scheme involved synthesis of the steroid building blocks (appropriately protected derivatives of pregn-17(20)-en-21-oic, 17 beta-hydroxypregnan-21-oic, and 17 alpha-hydroxypregnan-21-oic acids) and subsequent transformation of these building blocks into the target compounds. Following the developed scheme, synthesis of new nitrogen-containing steroid derivatives exhibiting antiandrogenic activity was enabled.

Reference of 76-37-9, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 76-37-9 is helpful to your research.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of C6H6FN, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 348-54-9, Name is 2-Fluoroaniline, molecular formula is C6H6FN. In an article, author is Yilmaz, Fatih,once mentioned of 348-54-9.

Synthesis and biological evaluation of some 1,3-benzoxazol-2(3H)-one hybrid molecules as potential antioxidant and urease inhibitors

A new series of 1,3-benzoxazol-2(3H)-one hybrid compounds, including coumarin, isatin 1,3,4-triazole and 1,3,4-thiadiazole moieties, were synthesized and biologically evaluated for their antioxidant capacities and anti-urease properties. The synthesized benzoxazole-coumarin (6a-e) and benzoxazole-isatin (10a-c) hybrids showed remarkable urease inhibitory activities with IC50(mu M), ranging from 0.0306 +/- 0.0030 to 0.0402 +/- 0.0030, while IC(50)of standard thiourea is 0.5027 +/- 0.0293. The synthesized benzoxazole-triazole (8a-c) and benzoxazole-thiadiazole (9a-c) hybrids showed similar urease inhibitory activities with IC50(mu M), ranging from 0.3861 +/- 0.0379 to 0.5126 +/- 0.0345. The antioxidant activity of the synthesized compounds was evaluated for their antioxidant activities, such as reducing power and ABTS (2,2 ‘-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt) radical scavenging. The results of ABTS radical scavenging activities of some of the synthesized molecules showed higher activities than standard Trolox, SC50(mu M) = 213.04 +/- 18.12. One benzoxazole-coumarin (6f), two benzoxazole-isothiocyanate (7b, 7c), and two benzoxazole-triazole (8b, 8c) derivatives showed higher activities (SC50(mu M) values, 82.07 +/- 10.34, 120.19 +/- 7.30, 104.58 +/- 10.55, 153.26 +/- 7.14, and 144.82 +/- 10.68, respectively) than standard Trolox, (SC50(mu M) = 213.04 +/- 18.12).

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1714-29-0, Name is 1-Bromopyrene, SMILES is BrC1=CC=C2C=CC3=CC=CC4=C3C2=C1C=C4, in an article , author is Saranya, Thachora Venu, once mentioned of 1714-29-0, Quality Control of 1-Bromopyrene.

Facile synthesis of 2-benzoxazoles via CuI/2,2′-bipyridine catalyzed intramolecular C-O coupling of 2-haloanilides

Development of newer methods for the synthesis of Benzoxazoles has of greater interest due to their wide range of biological activities and pharmaceutical importance. We herein report a facile and general method for the synthesis of 2-substituted Benzoxazoles via copper catalyzed intramolecular C-O cross-coupling of 2-haloanilides. A combination of CuI (5 mol%), 2,2′-bipyridine (10 mol%), Cs2CO3 (2 equiv.) in DMF solvent with 4 angstrom molecular sieves at 140 degrees C, illustrated the scope for tuning the reactivity of 2-haloanilides toward the selective formation of a series of 2-alkyl benzoxazole derivatives in moderate to good yields. This is the first systematic study using CuI/2,2′-Bipyridine as the catalytic system for the synthesis of 2-substituted Benzoxazoles. The outcome of the reaction was found to be significantly influenced by the aromatic and amide substituents of 2-haloanilides. [GRAPHICS]

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 1714-29-0, you can contact me at any time and look forward to more communication. Quality Control of 1-Bromopyrene.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Application of 421-85-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 421-85-2, Name is Trifluoromethanesulfonamide, SMILES is O=S(C(F)(F)F)(N)=O, belongs to benzoxazole compound. In a article, author is Sireesha, Reddymasu, introduce new discover of the category.

Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked beta-carboline derivatives

A new series of benzimidazole/benzoxazole linked beta-carbolines (9a-j) were rationally designed and synthesized by combining two different anti-cancer fragments. The new hybrid beta-carbolines are subjected to anti-cancer screening against four different human cancer cell lines such as MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by using standard MIT assay. These hybrid beta-carbolines exhibited significant and high fold anti-cancer activity against MCF-7 cell lines than reference standard. They are also proved to be effective against A549 and Colo-205 cell lines. Further, compound 9b, 9c from benzimidazole and 9i from benzoxazole series have exhibited maximum anti-cancer activity among these hybrid beta-carbolines. Later, all of the hybrid beta-carbolines were subjected to molecular interaction analysis against a few selected kinase targets such as cdc-like kinase (CLK-1 to CLK-4), epidermal growth factor reductase (EGFR) kinase, protein (ATR) kinase along with APC-Asef interface. The violin plot of binding energies of 9a-9j have suggested them as good kinase binders. Result interpretation suggested hybrid beta-carbolines as promising CLK binders. The anti-cancer data of new hybrid beta-carbolines against MCF-7 cell lines are in agreement with parent beta-carboline skeleton. (C) 2020 Elsevier B.V. All rights reserved.

Application of 421-85-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 421-85-2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem