Category: benzoxazole

1750-45-4, Name is 5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one, belongs to benzoxazole compound, is a common compound. 1750-45-4In an article, authors is Abbadi, Bruno L., once mentioned the new application about 1750-45-4.

Nonclinical evaluation of IQG-607, an anti-tuberculosis candidate with potential use in combination drug therapy

New effective compounds to treat tuberculosis are urgently needed. IQG-607 is an orally active anti-tuberculosis drug candidate, with promising preliminary safety profile and anti-mycobacterial activity in both in vitro and in vivo models of tuberculosis infection. Here, we evaluated the mutagenic and genotoxic effects of IQG-607, and its interactions with CYP450 isoforms. Moreover, we describe for the first time a combination study of IQG-607 in Mycobacterium tuberculosis-infected mice. Importantly, IQG-607 had additive effects when combined with the first-line anti-tuberculosis drugs rifampin and pyrazinamide in mice. IQG-607 presented weak to moderate inhibitory potential against CYP450 isoforms 3A4, 1A2, 2C9, 2C19, 2D6, and 2E1. The Salmonella mutagenicity test revealed that IQG-607 induced base pair substitution mutations in the strains TA100 and TA1535. However, in the presence of human metabolic S9 fraction, no mutagenic effect was detected in any strain. Additionally, IQG-607 did not increase micronucleus frequencies in mice, at any dose tested, 25, 100, or 250 mg/kg. The favorable activity in combination with first-line drugs and mild to moderate toxic events described in this study suggest that IQG-607 represents a candidate for clinical development.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1750-45-4

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

924869-17-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.924869-17-0, Name is Methyl benzo[d]oxazole-5-carboxylate, molecular formula is C9H7NO3. In a Article, authors is Sasmal, Swarnendu£¬once mentioned of 924869-17-0

Intermolecular coupling of 2-iodoanilides with benzoxazoles: Synthesis of N-(2-Benzoxazol-2-ylphenyl)benzamides via C-H activation

Using CuI/xantphos/Pd(OAc)2 catalytic system, the intermolecular C-C cross coupling between benzoxazoles and ortho-haloanilides has been developed in moderate to good yields. The procedure tolerates a series of functional groups on benzoxazole, such as ester, chloro, methyl, and methoxy groups. This divergent approach provides access to various N-(2-Benzoxazol-2-ylphenyl)amides.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 924869-17-0

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. 64037-07-6, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 64037-07-6

NOVEL COMPOUNDS AS MODULATORS OF GPR-119

The present invention relates to novel compounds of formula (A) and (B) as modulators of GPR-119, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of GPR-119 mediated diseases or disorders with them.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 64037-07-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 64037-07-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 70735-79-4, Name is 4-Acetylbenzo[d]oxazol-2(3H)-one,introducing its new discovery., 70735-79-4

Synthesis of 4-acetylbenzoxazolin-2(3H)-one reported from Zea mays

A three-step alternative synthesis of 4-acetylbenzoxazolin-2(3H)-one (4) is reported. Starting from inexpensive 3-hydroxyacetophenone (1) 3-hydroxy- 2-nitroacetophenone (2) is prepared by nitration followed by catalytic hydrogenation to yield 2-amino-3-hydroxyacetophenone (3) in which a C=O unit is inserted by means of bis(trichloromethyl)carbonate (triphosgene) in the presence of triethylamine to afford 4 in 35% overall yield.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 70735-79-4, help many people in the next few years.70735-79-4

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

122433-29-8, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 122433-29-8

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 122433-29-8, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 122433-29-8

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

375369-14-5, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.375369-14-5, Name is 6-Bromobenzo[d]oxazole, molecular formula is C7H4BrNO, introducing its new discovery.

CuCl-Catalyzed direct C-H alkenylation of benzoxazoles with allyl halides

An efficient and concise CuCl-catalyzed C2-alkenylation reaction of benzoxazoles with allyl halides has been established. The distinctive features of this protocol include the use of an inexpensive copper salt as a catalyst, simple and readily available starting materials, and ligand-free conditions. An important application of this method to the synthesis of 1,3-diene substituted benzoxazoles has also been achieved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 375369-14-5, help many people in the next few years.375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

4570-41-6, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 4570-41-6

IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE

Disclosed are compounds of formula (I), (II), (III), and (IV), and pharmaceutically acceptable salts thereof. The compounds are inhibitors of ALK2 kinase. Also provided are pharmaceutical compositions comprising a compound of formula (I), (II), (III), or (IV), or pharmaceutically acceptable salt thereof, and methods involving use of the compounds or pharmaceutically acceptable salts thereof and compositions in the treatment and prevention of various diseases and conditions, such as fibrodysplasia ossificans progressiva.

4570-41-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4570-41-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Because a catalyst decreases the height of the energy barrier, 4570-41-6, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4570-41-6, Name is Benzo[d]oxazol-2-amine, molecular formula is C7H6N2O. In a article£¬once mentioned of 4570-41-6

Access to Amide from Aldimine via Aerobic Oxidative Carbene Catalysis and LiCl as Cooperative Lewis Acid

Herein, an efficient route to amides from aldimines via aza-Breslow intermediates through aerobic oxidative carbene catalysis with LiCl as a cooperative Lewis acid is described. Many of the obtained N-heteroarylamides feature biological activity. Ambient air was used as the sole oxidant and source of oxygen in this catalytically oxidative amidation. This method allows for a broad substrate scope and mild conditions. The aza-Breslow intermediate derivative was isolated and its crystal structure confirmed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 4570-41-6, In my other articles, you can also check out more blogs about 4570-41-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

701-16-6, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 701-16-6

FLUORO-SUBSTITUTED BENZOXAZOLE POLYMETHINE DYES

Disclosed are reactive polyfluoro benzoxazole polymethine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which X is selected from the group consisting of -O-, -S- and at least one of groups R1 and R2 is the group -L-Rx or -L-Rp, where L is a linking group, Rx is a group suitable for covalent attachment of the dye to a component and Rp is a component; and at least one of groups R3, R4, R5, R6, R7, R8, R9 and R10 comprises fluorine. The use of polymethine dyes substituted by fluorine and having additional substitution by sulphonic acid groups, for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 701-16-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 701-16-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

5676-60-8, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 5676-60-8

METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

5676-60-8, Interested yet? Read on for other articles about 5676-60-8!

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem