Category: benzoxazole

Heteroleptic palladium(II) complexes containing N-heterocyclic carbenes and 4-phenyl-1H-1,2,3-triazole: Synthesis, characterization, and catalytic application was written by Chen, Wei;Yang, Jin. And the article was included in Journal of Coordination Chemistry in 2018.Electric Literature of C8H7NO2 This article mentions the following:

Reaction of the dimeric N-heterocyclic carbene (NHC) palladium compounds [Pd(μ-Cl)(Cl)(NHC)]₂ with 4-phenyl-1H-1,2,3-triazole gave four mono- and dinuclear complexes 1–4. Mononuclear complexes 1 and 2 [(NHC)PdCl₂(4-phenyl-1H-1,2,3-triazole)] were obtained when the reactions were performed in CH₂Cl₂, whereas dinuclear complexes 3 and 4 [Pd₂(μ-Cl)(μ-4-phenyl-1H-1,2,3-triazole)Cl₂(NHC)₂] were obtained when the reactions were performed in THF in reflux with Et₃N as the base. Further explorations of the catalytic properties of for Pd-catalyzed transformations were performed and these complexes exhibited moderate to high catalytic activities for Suzuki-Miyaura coupling and arylation of benzoxazoles with aryl bromides. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Electric Literature of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Electric Literature of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

TEMPO/PhI(OAc)₂-mediated Direct Sulfoximination of Benzoxazoles under Metal-free Conditions was written by Wang, Jian;Tu, Changqing;Feng, Mei-Lin;Li, Nan. And the article was included in Chemistry Letters in 2022.HPLC of Formula: 132227-03-3 This article mentions the following:

A metal-free reaction system consisting of TEMPO and PhI(OAc)₂ for the oxidative C-N coupling of benzoxazoles with NH-sulfoximines had been developed to obtain arylsulfoximines I [R¹ = H, 5-Cl, 7-Br, etc.; R² = Me, Et, n-Bu, Bn; R³ = Ph, 4-FC₆H₄, 2-BrC₆H₄, etc.]. The reaction could proceed under ambient atm. without any metal catalyst at room temperature to afford the corresponding 2-iminoazoles in moderate to high yields. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3HPLC of Formula: 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.HPLC of Formula: 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes as precatalysts for direct arylation of azoles with aryl bromides was written by Yang, Jin. And the article was included in Tetrahedron in 2019.Computed Properties of C8H7NO2 This article mentions the following:

A series of mixed N-heterocycles/N-heterocyclic carbene palladium(II) allyl complexes with general formula [(NHC)Pd(η³-allyl)]₂(μ₂-N-heterocycles)(BF₄)₂ were prepared in one pot based on anion metathesis of (NHC)Pd(η³-allyl)Cl complexes and then ligand replacement with N-heterocycles [N-heterocycles = pyrazine (pyz), 4,4′-bipyridine (bpy) and trans-4,4′-bipyridylethylene (bpe)]. The solid-state structures showed dinuclear structures with two palladium(II) centers holding together by bridged N-heterocycles. Initially investigation of the obtained complexes as precatalysts for direct C-H bond arylation of azoles with aryl bromides was carried out. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Computed Properties of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Computed Properties of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Abnormal-NHC-Supported Nickel Catalysts for Hydroheteroarylation of Vinylarenes was written by Vijaykumar, Gonela;Jose, Anex;Vardhanapu, Pavan K.;P, Sreejyothi;Mandal, Swadhin K.. And the article was included in Organometallics in 2017.Category: benzoxazole This article mentions the following:

Herein the authors report the hydroheteroarylation of vinylarenes with benzoxazole in the presence of a free abnormal N-heterocyclic carbene and Ni(COD)₂, resulting in 1,1-diarylethane products exclusively. In an attempt to understand the mechanism of this catalytic reaction, two abnormal-NHC (aNHC)-coordinated Ni(II) cyclooctenyl complexes were isolated and their solid-state structures were determined by x-ray crystallog. studies. These Ni(II) cyclooctenyl complexes act as active catalyst precursors to generate in situ aNHC-Ni(0) species, which undergo oxidative addition with heteroarene to form Ni(II) hydride intermediates. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Category: benzoxazole).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Palladium-catalyzed trisallylation of benzoxazoles and 2-aryl-1,3,4-oxadiazoles with alkyne was written by Zheng, Jun;Hosseini-Eshbala, Fereshteh;Dong, Ya-Xi;Breit, Bernhard. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Recommanded Product: 132227-03-3 This article mentions the following:

A Pd-catalyzed direct C-H trisallylation of azoles with alkyne has been described. A consecutive C(sp²)-H allylation/olefin isomerization/double C(sp³)-H allylation of azoles and alkyne via a palladium catalysis system proceeds efficiently to afford the corresponding C2-alkenylated azoles containing an all quaternary carbon center. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Recommanded Product: 132227-03-3).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen and tafamidis.Recommanded Product: 132227-03-3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

C-H Bond Functionalization of Benzoxazoles with Chromium(0) Fischer Carbene Complexes was written by Hu, Fangdong;Yang, Jinghui;Xia, Ying;Ma, Chen;Xia, Haiping;Zhang, Yan;Wang, Jianbo. And the article was included in Organometallics in 2016.Electric Literature of C8H7NO2 This article mentions the following:

An efficient C-H bond functionalization of benzoxazoles with chromium(0) Fischer carbene complexes under catalyst-free conditions has been developed. A series of benzoxazoles and chromium(0) carbene complexes are compatible with the reaction. This transformation provides an alternative way for C-H bond alkylation of benzoxazoles. In the reaction mechanism the elimination of the Cr(CO)₅ fragment seems more favored than the elimination of an alkoxy group, which is in sharp contrast to the previous reports on the reaction of organolithium reagents with chromium(0) Fischer carbene complexes. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Electric Literature of C8H7NO2).

5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Electric Literature of C8H7NO2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

New flowsheet for the treatment of complex sulfide ores using synthetic collectors was written by Belardi, G.;Alesse, V.;Marabini, A. M.. And the article was included in Minerals & Metallurgical Processing in 1995.COA of Formula: C8H7NOS This article mentions the following:

An alternative flowsheet was designed for the flotation treatment of a complex sulfide ore from the Sotiel Mine in Spain. The ore contains 0.71% Cu, 2.24% Pb and 5.63% Zn. Two specially developed synthetic collectors, methylmercapto-benzoxazole (MMBO) and 6n-propoxy-mercaptobenzo-thiazole (PMBT), were examined MMBO exerts a specific action on copper and zinc minerals after treatment with copper sulfate, and PMBT exerts a specific action on Pb minerals. Flotation operating variables (pH, frother type, frother quantity and feed particle size) were examined by means of rougher flotation tests to determine the optimum conditions for the new collectors. Once the optimum conditions were determined, a series of open flotation circuits were run on feeds of various particle sizes (obtained by different types of grinding). The objective was to obtain high-grade Cu and zn concentrates The results of the open-circuit tests demonstrated that a Cu concentrate grading from 18% to 23% Cu and a Zn concentrate grading from 40% to 48% Zn can be produced. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0COA of Formula: C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.COA of Formula: C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthesis of 2-(benzylthio)benzimidazole, 2-[(benzimidazol-2-yl)methylthio]benzimidazole and structural analogues against Haemonchus contortus was written by Akpa, Sagne Jacques;Say, Martial Venance;Zoakouma, Roger Simplice Pepin;Fante, Bamba;Sissouma, Drissa;Adjou, Ane. And the article was included in African Journal of Pharmacy and Pharmacology in 2016.Synthetic Route of C8H7NOS This article mentions the following:

The coupling of 2-mercaptobenzimidazoles with (chloromethyl)benzene derivatives gave 2-(benzylthio)benzimidazoles I (R¹ = H, NO₂, C₆H₅CO; R² = H, 4-Cl, 3-NO₂, 2,4-Cl) on one hand, and coupling with the 2-(chloromethyl)benzimidazoles on the other gave 2-[(benzimidazolyl)methylthio]benzimidazoles and analogs II (R⁴ = H, 6-CH₃, 5-NO₂, etc.; R³ = H, NO₂, C₆H₅CO; X = NH, S, O). The evaluation of the anthelmintic activities of these mols. on Haemonchus contortus showed that the introduction of the nitro group (NO₂) in the structure causes a significant increase of the activity. Among the mols. evaluated in vitro for their anti-infectious activity, compounds I (R¹ = H; R² = 3-NO₂) and II (R¹ = 5-NO₂, 5-C₆H₅CO; R² = H, NO₂, C₆H₄CO) revealed an activity which is comparable to that of the reference mols. (ivermectin and fenbendazole). In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Synthetic Route of C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization. The wide range in therapeutic potential of benzoxazole derivatives is related to the favourable interactions of the benzoxazole moiety with different protein targets.Synthetic Route of C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Regioselective Thiolation of Arenes and Heteroarenes: C-H Functionalization Strategy for C-S Bond Formation was written by Varun, Begur Vasanthkumar;Prabhu, Kandikere Ramaiah. And the article was included in Journal of Organic Chemistry in 2014.Formula: C8H7NOS This article mentions the following:

A facile transition-metal-free oxidative cross-dehydrogenative coupling reaction involving selective formation of a C-S bond leading to the synthesis of arylthiobenzoxazoles, heteroarylthiobenzoxazoles, and arylthiobenzothiazoles has been described. This highly regioselective C-H functionalization reaction with electron-rich aromatic systems including heteroaromatics is achieved by reversing the reactivity of sulfur in the presence of a suitable oxidant and strong acid. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Formula: C8H7NOS).

6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Benzoxazole nucleus is one of the most important heterocyclic compounds exhibiting remarkable pharmacological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Formula: C8H7NOS

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem