Category: benzoxazole

On March 1, 2022, Ma, Tiantian; Zheng, Yiyi; Xu, Jiacong published a patent.Category: benzoxazole The title of the patent was Preparation of heterocyclic nitrogen compounds for organic electroluminescent device. And the patent contained the following:

The present invention relates to the preparation of heterocyclic nitrogen compounds for organic electroluminescent device. In particular, the preparation of compound I (wherein, * represents a connection site, ring A, B and C = C6-14 aryl and are not benzene rings at the same time; in formula II * is the bond which represents fusion on any two adjacent carbon atoms of ring B in I; U1, U2 = (un)substituted [C6-30 aryl, C3-30 heteroaryl] or a structure shown in formula III or IV, and at least one of U1 and U2 is selected from formula III or IV; X = S or O; X1, X2 and X3 = N or C(R), and at least one of X1, X2 and X3 is N; E1 = (R1)n1; E2 = (R2)n2; E3 = (R3)n3; E4 = (R4)n4; E5 = (R5)n5; R1-5 = hydrogen, deuterium, halogen, cyano, C6-12 aryl, C5-12 heteroaryl, C1-5 alkyl, C1-5 haloalkyl, C1-5 deuterated alkyl, C3-12 trialkylsilyl). Further, (n1, n2 represents the number of substituents R1 and R2 resp.; n1, n2 = 1-8, when n1 or n2 is greater than 1, any two R’s are the same or different, optionally, any two adjacent R’s form a ring; n3 represents the number of substituent R3, n3 = 1-6, when n3 is greater than 1, any two R3 are the same or different, optionally, any two adjacent R3 form a ring; n4 represents the number of substituent R4, n4 = 1-3, when n4 is greater than 1, any two R4 are the same or different, any optionally, any two adjacent R4 form a ring). Also, (n5 represents the number of substituent R5, n5 = 1-4, when n5 is greater than 1, any two R5 is the same or different, optionally, any two adjacent R5 form a ring; L, L1-4 = a single bond, (un)substituted [C6-30 arylene, C3-30 heteroarylene]; Ar1 and Ar2 = (un)substituted [C6-30 aryl, C3-30 heteroaryl]; the substituents in the U1, U2, L, L1-4, Ar1 and Ar2 = deuterium, halogen, cyano, C3-20 heteroaryl, C6-20 aryl, C3-12 trialkylsilyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 deuterated alkyl, C3-10 cycloalkyl, C2-10 heterocycloalkyl or C1-10 alkoxy; optionally, in Ar1 and Ar2, any two adjacent substituents form a ring). The inventive compound having a fused heteroaromatic ring as a hole transporting group and a nitrogen-containing heteroaryl group as an electron transporting group is suitable for use in an organic electroluminescent device, and the performance of the organic electroluminescent device can be significantly improved. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Category: benzoxazole

The Article related to heterocyclic nitrogen compound preparation hole transport material oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 2, 2021, Yang, Min published a patent.Formula: C13H8BrNO The title of the patent was Preparation of triazine derivatives and their application in OLED. And the patent contained the following:

The present invention relates to preparation of triazine derivatives and their application in OLED. In particular the preparation of compound containing I, II and III (wherein, * represents the connection site of I and II; I is connected to the two adjacent connection points in II; A is the connection site of III; wherein, ring B represents C10-20 aromatic ring; X = S or O; Het = C3-20 heteroarylene group and contains at least two N atoms ; L1, L2 and L3 = a single bond, (un)substituted C6-30 arylene, C3-30 heteroaryl; Ar1, Ar2 and Ar3 = hydrogen, (un)substituted C6-30 aryl or C3-30 heteroaryl groups; the substituents in L1, L2, L3, Ar1, Ar2 and Ar3 = deuterium, halogen, cyano, C3-20 heteroaryl, C6-20 aryl, C1-10 alkyl, C1-10 haloalkyl, C2-10 heterocycloalkyl, C1-10 alkoxy; optionally, in Ar1 and Ar2, any two adjacent substituents form a ring). Further, (R1, R2 and R3 = hydrogen, deuterium, halogen, cyano, C6-C20 aryl, C3-C30 heteroaryl, C3-C12 trialkylsilyl, C1-C10 alkyl, C1-10 haloalkyl, C3-10 cycloalkyl, C2-10 heterocycloalkyl or C1-10 alkoxy; n1 = 1, 2, 3 or 4; when n1 is greater than 1, any two R1s are the same or different, optionally, any two adjacent R1 form a ring; n2 = 1 or 2; when n2 is greater than 1, any two R2s are the same or different, optionally, any two adjacent R2s form a ring; n3 = 1, 2, 3, or 4; when n3 is greater than 1, any two R3s are the same or different, and optionally, any two adjacent R3s form a ring). The inventive triazine compound can effectively improve the light-emitting efficiency of the device, reduce the voltage of the device and prolong the service life of the organic electroluminescent device. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Formula: C13H8BrNO

The Article related to triazine derivative preparation organic electroluminescent device, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On June 25, 2021, Ma, Tiantian; Zhang, Kongyan; Li, Xinxuan; Zheng, Yiyi published a patent.Synthetic Route of 1268137-13-8 The title of the patent was Nitrogen-containing compound, electronic component and electronic device containing the same. And the patent contained the following:

The present invention relates to a nitrogen-containing compound that is represented by the formula I, wherein A and B are independently C6-C30 (un)substituted aryl, aryl, etc.; U1, U2 and U3 are independently selected from N or C(R), and at least one of U1, U2 and U3 is N; each of R, R1, R2, R3, R4, and R5 is independently selected from hydrogen, deuterium, halogen group, cyano group, etc.; n1, n2, n3, n4, n5 are selected from 1, 2, 3 or 4, when n1-n5 is greater than 1; X is selected from S or O; L, L1, L2, L3 and L4 are independently selected from single bonds, (un)substituted arylene groups having 6-30 carbon atoms, and (un)substituted heteroarylene group having 3-30 carbon atoms; and Ar1 and Ar2 are independently selected from (un)substituted aryl groups having 6-30 carbon atoms, and (un)substituted heteroaryl groups having 3-30 carbon atoms. The nitrogen-containing compound can be used in the light-emitting layer material of an organic electroluminescent device, improving the electron transport performance of the device, and improving the luminous efficiency and service life of the device. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Synthetic Route of 1268137-13-8

The Article related to nitrogen carbazole heterocyclic compound application oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On July 12, 2022, Zhang, Kongyan; Ma, Tiantian; Zhang, Heming published a patent.Formula: C13H8BrNO The title of the patent was Carbazole-triazine compound, and electronic element and electronic device using same. And the patent contained the following:

The present application relates to an organic compound and electronic component and electronic device using the same. The organic compound has a structure represented by the following formula 1, wherein A1 and A2 are independently selected from a structure represented by formula 2 or formula 3; m is 1 or 2. The organic compounds provided herein can be used in an organic electroluminescent device to improve the performance of the organic electroluminescent device. The application relates to carbazole-triazine compounds I, and electronic elements and electronic devices using same. Compounds of formula I wherein T is -(L3-L4-A2)m; A1 and A2 are independently (un)substituted benzoxazolyl, (un)substituted triazinyl, etc.; m is 1-2; L1-L4 are independently a single bond, (un)substituted C6-30 arylene, C2-30 heteroarylene; R1 and R2 are independently D, halo, C1-10 alkyl, C3-10 cycloalkyl, C1-10 alkoxy, C6-30 aryl, etc.; n1 and n2 are independently 0-4; and their preparation method, as well as the use in OLEDs thereof, are claimed. Example compound II was prepared by using reductive cyclization, Suzuki cross coupling and condensation as the key steps. The organic compounds I provided in the present application can be used in organic electroluminescent devices, and can improve the performance of the organic electroluminescent devices. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Formula: C13H8BrNO

The Article related to carbazole triazine preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Formula: C13H8BrNO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On July 14, 2022, Zhang, Kongyan; Ma, Tiantian; Zhang, Heming published a patent.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Carbazole-triazine compound, and electronic element and electronic device using same. And the patent contained the following:

The application relates to carbazole-triazine compounds I, and electronic elements and electronic devices using same. Compounds of formula I wherein T is -(L3-L4-A2)m; A1 and A2 are independently (un)substituted benzoxazolyl, (un)substituted triazinyl, etc.; m is 1-2; L1-L4 are independently a single bond, (un)substituted C6-30 arylene, C2-30 heteroarylene; R1 and R2 are independently D, halo, C1-10 alkyl, C3-10 cycloalkyl, C1-10 alkoxy, C6-30 aryl, etc.; n1 and n2 are independently 0-4; and their preparation method, as well as the use in OLEDs thereof, are claimed. Example compound II was prepared by using reductive cyclization, Suzuki cross coupling and condensation as the key steps. The organic compounds I provided in the present application can be used in organic electroluminescent devices, and can improve the performance of the organic electroluminescent devices. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to carbazole triazine preparation oled, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On March 5, 2020, Mete, Antonio; Hitchin, James R.; Graham, Mark published a patent.Safety of Methyl benzo[d]oxazole-7-carboxylate The title of the patent was Heterocyclic compounds as ARH modulators for treatment of diseases, in particular cancer. And the patent contained the following:

The present invention relates compounds of the general formula (I) or (II) which are ARH inhibitors, methods for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds and pharmaceutical compositions for the treatment or prevention of diseases, in particular cancer or conditions with dysregulated immune functions, or other conditions associated with aberrant AHR signaling, as a sole agent of in combination with other active ingredients. Such compounds may also be of utility in the expansion of hematopoietic stem cells (HSCs) and the use of HSCs in autologous or allogenic transplantation for the treatment of patients with inherited immunol. and autoimmune diseases and diverse hematopoietic disorders. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Safety of Methyl benzo[d]oxazole-7-carboxylate

The Article related to heterocyclic arh modulator signaling cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of Methyl benzo[d]oxazole-7-carboxylate

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On January 6, 2022, Tobita, Hidekatsu; Nakano, Takaaki; Nokura, Yoshihiko published a patent.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Method for controlling soybean rust fungus having resistance to QOI fungicide. And the patent contained the following:

The invention relates to a method for controlling soybean rust fungus using a compound that has an amino acid substitution of F129L in the mitochondrial cytochrome b protein. The compound is represented by formula (I) I [wherein, R1 = C1-4 alkyl group or the like, n = 0, 1, or 2, Q = a group or the like represented by Q1, a binding site with respect to the remaining portion of the mol., X1 = -C(H)= or the like, X2 represents -C(O)OCH3 or the like, J is a group or the like represented by J1, indicates a binding position with respect to E, Y1 = oxygen atom or the like, Y2 = C(R6)- or the like, R6 = C1-4 alkyl group or the like, and E = C1-6 chain-like hydrocarbon group or the like]. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to qoi fungicide resistant soybean rust fungus control, Agrochemical Bioregulators: Microbial and other aspects.Quality Control of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 23, 2021, Gao, Chunji; Zhao, Xiaoyu published a patent.Safety of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Preparation of heterocyclic compound as light emitting host material layer for organic electroluminescent device. And the patent contained the following:

The invention relates to preparation of heterocyclic compound as light emitting host material layer for organic electroluminescent device. In particular, the heterocyclic compound as light emitting host material layer I or II (wherein, Ar1 – Ar4 = (un)substituted C6-C30 aryl or (un)substituted C3-C30 heteroaryl groups; X1 – X4 = C or N; Y1 and Y2 = NR1 or O; R1 = (un)substituted C1-C20 alkyl, (un)substituted C6-30 aryl or (un)substituted C3-C30 heteroaryl group; L1 and L2 = single bond, (un)substituted C6-C30 arylene, or (un)substituted C3-C30 heteroarylene group). Further, (R2 – R9 = H, D, halogen, cyano, carboxy, nitro, hydroxyl, (un)substituted C1-C20 alkyl, (un)substituted C3-C30 cycloalkyl, (un)substituted C3-C30 cycloalkenyl group, (un)substituted C3-C7 heterocycloalkyl, (un)substituted C6-C30 aryl, (un)substituted C3-C30 heteroaryl; or adjacent ones of R2 to R9 may be connected to each other to form one or more rings, the premise is that at least one pair of R2 and R3, R3 and R4, R4 and R5, R5 and R6, R6 and R7, R7 and R8, and R8 and R9 may be connected to each other to form one or more rings, wherein the ring has 1 to 5 single rings) was prepared The organic electroluminescent device of the present invention has excellent luminous efficiency and lifetime. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Safety of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to oxazolophenanthridine derivative preparation light emitting host material oled, imidazophenanthridine derivative preparation light emitting host material oled, carbazole derivative preparation light emitting host material oled and other aspects.Safety of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On January 20, 2016, Lee, Ha-Rim; Farhanullah; Lee, JiSoo; Jajoo, Rahul; Kong, Sun-Young; Shin, Jae-Yeon; Kim, Jae-Ouk; Lee, Jiyoun; Lee, Jeewoo; Kim, Hyun-Jung published an article.Recommanded Product: 1268137-13-8 The title of the article was Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells. And the article contained the following:

Identification of small mols. that direct neural stem cells (NSCs) into specific cell types would be helpful to understand the mol. mechanisms involved in regulation of NSC fate, and facilitate the development of therapeutic applications. In the current study, we developed and screened small mols. that can modulate the fate of NSCs that are derived from rat fetal cortex. Among these compounds, compounds 5 and 6 successfully differentiated NSCs into astrocytes and neurons, resp. Compound 5 induced astrocytogenesis by increasing expression of interleukin-6, bone morphogenetic protein 2 and leukemia inhibitory factor and through consequent phosphorylation of signal transducer and activator of transcription 3 and Sma- and Mad-related protein 1/5/8 in NSCs. In addition, compound 5 increased the expression of fibroblast growth factor (FGF) 2 and FGF8 which may regulate the branching and morphol. of astrocytes. Taken together, our results suggest that these small mols. can serve as a useful tool to study cell fate determination in NSCs and be used as an inexpensive alternative to cytokines to study mechanisms of astrocytogenesis. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Recommanded Product: 1268137-13-8

The Article related to benzothiazole derivative preparation structure activity astrocytogenesis stat3 smad erk, astrocytogenesis, differentiation, neural stem cells, neurodegeneration, neurological agents, structure−activity relationships and other aspects.Recommanded Product: 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 15, 2021, Jie, liu; Ye, Wan; Xu, Jiang-Ping; Wang, Hai-Tao; Li, Xiao-Fang; Wang, Wen-Ya; Zhou, Zhong-Zhen published an article.Category: benzoxazole The title of the article was Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells. And the article contained the following:

To discover PDE4/tubulin dual inhibitors with novel skeleton structures, 7-trimethoxyphenylbenzo[d]oxazoles I [R1 = R2 = H, MeO; R3 = C6H5, 4-MeO-C6H4, 3-F-C6H4, etc] and 4-trimethoxyphenylbenzo[d]oxazoles II [R4 = C6H5, 3,4-MeO-C6H3, 4-F-C6H4, etc] were designed and synthesized by migrating the trimethoxyphenyl group of TH03 to the benzo[d]oxazole moiety. Among these compounds, approx. half of them displayed good antiproliferative activities against glioma (U251) and lung cancer (A549 and H460) cell lines. The structure-activity relationships of trimethoxyphenylbenzo[d]oxazoles led to the identification of I [R1 = H; R2 = MeO; R3 = 1H-indol-5-yl] bearing indol-5-yl side-chain as a novel dual PDE4/tubulin inhibitor, which exhibited satisfactory antiproliferative activities against glioma (IC50 = 300 ± 50 nM) and lung cancer (average IC50 = 39.5 nM) cells. Further investigations revealed that I [R1 = H; R2 = MeO; R3 = 1H-indol-5-yl] induced apoptosis at G2/M phase arrest and disrupted the microtubule network. The preliminary mechanism of action showed that I [R1 = H; R2 = MeO; R3 = 1H-indol-5-yl] down-regulated the expression of cyclin B1 and its upstream regulator gene cdc25C in A549. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Category: benzoxazole

The Article related to trimethoxyphenylbenzoxazole preparation tubulin inhibitor antiproliferative sar, antiproliferative activities, apoptosis, cell cycle arrest, dual pde4/tubulin inhibitor, trimethoxyphenylbenzo[d]oxazole and other aspects.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem