Category: benzoxazole

Saha, Prasenjit; Ramana, Tamminana; Purkait, Nibadita; Ali, Ashif Md; Paul, Rajesh; Punniyamurthy, Tharmalingam published the article 《Ligand-Free Copper-Catalyzed Synthesis of Substituted Benzimidazoles, 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and Benzoxazoles》. Keywords: benzimidazole aminobenzimidazole aminobenzothiazole benzoxazole preparation; intramol cyclization bromoaryl derivative copper oxide nanoparticle catalyst.They researched the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3 ).Product Details of 6797-13-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6797-13-3) here.

The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramol. cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. E.g., cyclization of o-bromoaryl amidine I gave 95% benzimidazoles II. The procedure is exptl. simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity.

Compound(6797-13-3)Product Details of 6797-13-3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Ethylbenzo[d]oxazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Reduction of α-furyl ketones by chemical methods at different potentials. Properties and physical-chemical studies of the different compounds obtained》. Authors are Morizur, Jean Pierre; Wiemann, Joseph.The article about the compound:1-(Furan-2-yl)propan-1-onecas:3194-15-8,SMILESS:O=C(C1=CC=CO1)CC).Electric Literature of C7H8O2. Through the article, more information about this compound (cas:3194-15-8) is conveyed.

α-Furyl alkyl ketones were reduced by Zn (E0  0.75 v.) in AcOH, Mg (E0 = 2.5 v.) in AcOH, and Na amalgam (E0 = 2.7 v.) in H2O. The products were characterized by infrared (IR) and nuclear magnetic resonance (NMR) spectra. The following ketones were prepared by known methods [alkyl group and b.p. (mm.) given]: Me (I), 69° (15); Et (II), 74-6° (11); Pr (III), 96° (20). To a stirred suspension of 50 g. Zn in 500 ml. H2O at 50° was added over 3 hrs. 1 mole ketone in 100 g. AcOH simultaneously with 50 g. Zn and the mixture stirred 1 hr. to give the following results. I gave 2.5 g. IV, b0.05 80-2°, m. 121-2° (benzene), and 27.5 g. 2,3-di-2-furylbutane-2,3-diol (V), b0.05 92-4°. II and III gave, resp., 25 g. 3,4-di-2-furylhexane-3,4-diol (VI), b0.05 96-8°, and 28 g. 4,5-di-2-furyloctane-4,5-diol (VII), b0.05 104-6°. To a stirred mixture of 1 mole ketone in 500 ml. H2O at 100°, 72 g. Mg was added in small portions with dropwise addition of 400 g. 90% AcOH over 6 hrs. to give (from I) 5 g. IV, 27 g. V, and 32 g. VIII (R = Me), b0.05 102-5°, (from II) 30 g. VI, 36 g. VIII (R = Et), b0.05 106-9°, and (from III) 15 g. VII, 18 g. VIII (R = Pr), b0.05 111-13°. One mole I was reduced at -35° by 34.5 g. Na as an amalgam ( CA 55, 363d) to give 8 g. IV, 7 g. V, m. 47-8°, and 3 g. VIII (R  Me). Hydrogenation of IV by LiAlH4 in ice-cold Et2O gave IX, m. 98-100° (benzene). Similar treatment of the γ-ketols gave dihydroxy compounds melting over a 30-40° range.

Compound(3194-15-8)Electric Literature of C7H8O2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 503538-69-0, is researched, SMILESS is FC1(F)OC2=CC=C(P(C3=CC=CC=C3)C4=CC=CC=C4)C(C5=C6OC(F)(F)OC6=CC=C5P(C7=CC=CC=C7)C8=CC=CC=C8)=C2O1, Molecular C38H24F4O4P2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Access to enantioenriched α-amino esters via rhodium-catalyzed 1,4-addition/enantioselective protonation, Author is Navarre, Laure; Martinez, Remi; Genet, Jean-Pierre; Darses, Sylvain, the main research direction is amino acid ester asym preparation; aryltrifluoroborate amino acrylate conjugate addition protonation rhodium.Recommanded Product: 503538-69-0.

Conjugate addition of potassium trifluoro(organo)borates to dehydroalanine derivatives, mediated by a chiral rhodium catalyst and in situ enantioselective protonation, afforded straightforward access to a variety of protected α-amino esters with high yields and enantiomeric excesses up to 95%. Among the tested chiral ligands and proton sources, Binap, in combination with guaiacol (2-methoxyphenol), an inexpensive and nontoxic phenol, afforded the highest asym. inductions. Organostannanes have also shown to participate in this reaction. By a fine-tuning of the ester moiety, and using Difluorophos as chiral ligand, increased levels of enantioselectivity, generally close to 95%, were achieved. Deuterium labeling experiments revealed, and DFT calculation supported, an unusual mechanism involving a hydride transfer from the amido substituent to the α carbon explaining the high levels of enantioselectivity attained in controlling this α chiral center.

Compound(503538-69-0)Recommanded Product: 503538-69-0 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Category: benzoxazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Furan-2-yl)propan-1-one, is researched, Molecular C7H8O2, CAS is 3194-15-8, about 1,4-Addition in the furan series. I. Condensation of benzylmagnesium bromide with α-furyl ketones. Author is Berreby, Edgar; Morizur, Jean P.; Wiemann, Joseph.

A mixture of 27.5 g. 2-acetylfuran in 50 cc. ether was refluxed 1 hr. with PhCH2MgBr prepared from 42.75 g. PhCH2Br and hydrolyzed with HCl to give 10 g. of the starting material and 34 g. of a mixture, b0.01 82-92°. This mixture was redistilled to give 18% dibenzyl, b5 115-17°, 20% 1-phenyl-2-furyl-2-propanol, b5 123°, and 30% 2-acetyl-3-benzyl-2,3-dihydrofuran, b7 131°. Similar treatment of ethyl 2-furyl ketone gave 31.5 g. of a mixture containing 11% dibenzyl, 24% 1-phenyl-2-furyl-2-butanol, b6 136°, and 24% 2-propionyl-3-benzyl-2,3-dihydrofuran, b6 131°. N.M.R. and ir data are given.

Compound(3194-15-8)Category: benzoxazole received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of C9H9NO. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Ethylbenzo[d]oxazole, is researched, Molecular C9H9NO, CAS is 6797-13-3, about Ag@TiO2 nanocomposite; synthesis, characterization and its application as a novel and recyclable catalyst for the one-pot synthesis of benzoxazole derivatives in aqueous media. Author is Maleki, Behrooz; Baghayeri, Mehdi; Vahdat, Seyed Mohammad; Mohammadzadeh, Abbas; Akhoondi, Somaieh.

A series of benzoxazole derivatives I (R = H, 3-NO2C6H4, CH2CH3, 3-CH3OC6H4, etc.) were synthesized via Ag@TiO2 nanocomposite catalyzed one-pot condensation of 2-aminophenol and several aromatic aldehydes or orthoesters or carboxylic acids or amides or acyl chlorides in water at room temperature with excellent yields. The short reaction times, high yields, safety and mild conditions, simplicity, non-toxicity and easy workup were the main merits of this protocol.

Compound(6797-13-3)Synthetic Route of C9H9NO received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Ethylbenzo[d]oxazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(Furan-2-yl)propan-1-one( cas:3194-15-8 ) is researched.Category: benzoxazole.Paravisini, Laurianne; Prot, Aurelie; Gouttefangeas, Cecile; Moretton, Cedric; Nigay, Henri; Dacremont, Catherine; Guichard, Elisabeth published the article 《Characterisation of the volatile fraction of aromatic caramel using heart-cutting multidimensional gas chromatography》 about this compound( cas:3194-15-8 ) in Food Chemistry. Keywords: caramel cooking aroma volatile furan lactone acid; Caramel; Heart-cutting multidimensional gas chromatography (MDGC); Mass Spectrometry; Odorant compounds; Olfactometry. Let’s learn more about this compound (cas:3194-15-8).

The first aim of the study was to improve characterization of the volatile fraction of aromatic caramel by applying heart-cutting multidimensional gas chromatog. coupled to mass spectrometry and olfactometry (MDGC-MS-O) on targeted odorant fractions. The second aim was to compare the volatile composition of two caramel samples, which differed in terms of their carbohydrate composition and cooking process. MDGC analyses enabled identification of 37 compounds (17 with the addition of pure standard) in the burnt sugar caramel, 20 of which were reported for the first time in caramel. Fifteen compounds were identified as odor-active and described using a range of attributes such as floral, roasted, spicy and almond. Furans, lactones and acids resulting from the thermal breakdown of sugars predominated in the volatile fraction of the burnt sugar caramel, due to the harsher cooking conditions. These results have enabled a clearer understanding of aromatic caramel as well as the identification of new compounds which might make an important contribution to its aroma.

Compound(3194-15-8)Category: benzoxazole received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

COA of Formula: C38H24F4O4P2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Pd/Zn Co-catalyzed Asymmetric Ring-opening Reactions of Aza/Oxabicyclic Alkenes with Oximes. Author is Shen, Guoli; Khan, Ruhima; Yang, Fan; Yang, Yong; Pu, Dongdong; Gao, Yang; Zhan, Yong; Luo, Yang; Fan, Baomin.

An application of various oximes as nucleophiles in the asym. ring-opening (ARO) reaction of aza/oxabicyclic alkenes resulting in cis-ARO products has been developed. The reaction was co-catalyzed by Pd(OAc)2 and Zn(OTf)2 with (R)-DIFLUORPHOS as the chiral ligand. This methodol. exhibits broad substrate scope, functional group tolerance with high enantioselectivity. A synthetic application of this method has been demonstrated.

Compound(503538-69-0)COA of Formula: C38H24F4O4P2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Robinson, Anthony L.; Boss, Paul K.; Heymann, Hildegarde; Solomon, Peter S.; Trengove, Robert D. researched the compound: 1-(Furan-2-yl)propan-1-one( cas:3194-15-8 ).Application of 3194-15-8.They published the article 《Development of a sensitive non-targeted method for characterizing the wine volatile profile using headspace solid-phase microextraction comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry》 about this compound( cas:3194-15-8 ) in Journal of Chromatography A. Keywords: wine flavor headspace solid microextraction GC MS. We’ll tell you more about this compound (cas:3194-15-8).

Future understanding of differences in the composition and sensory attributes of wines require improved anal. methods which allow the monitoring of a large number of volatiles including those present at low concentrations This study presents the optimization and application of a headspace solid-phase microextraction (HS-SPME) method for anal. of wine volatiles by comprehensive two-dimensional gas chromatog. (GC × GC) time-of-flight mass spectrometry (TOFMS). This study demonstrates an important advancement in wine volatile anal. as the method allows for the simultaneous anal. of a significantly larger number of compounds found in the wine headspace compared to other current single dimensional GC-MS methodologies. The methodol. allowed for the simultaneous anal. of over 350 different tentatively identified volatile and semi-volatile compounds found in the wine headspace. These included potent aroma compound classes such as monoterpenes, norisoprenoids, sesquiterpenes, and alkyl-methoxypyrazines which have been documented to contribute to wine aroma. It is intended that wine aroma research and wine sensory research will utilize this non-targeted method to assess compositional differences in the wine volatile profile.

Compound(3194-15-8)Application of 3194-15-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-(Furan-2-yl)propan-1-one), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Computed Properties of C8H8N2S. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Toxicity Study of a Rubber Antioxidant, Mixture of 2-Mercaptomethylbenzimidazoles, by Repeated Oral Administration to Rats. Author is Saitoh, M.; Umemura, T.; Kawasaki, Y.; Momma, J.; Matsushima, Y.; Sakemi, K.; Isama, K.; Kitajima, S.; Ogawa, Y.; Hasegawa, R.; Suzuki, T.; Hayashi, M.; Inoue, T.; Ohno, Y.; Sofuni, T.; Kurokawa, Y.; Tsuda, M..

2-Mercaptobenzimidazole (2-MBI), a rubber antioxidant, is known to exhibit potent antithyroid toxicity in rats and is a candidate as an environmental endocrine disrupter. 2-Mercaptomethylbenzimidazoles (a 1:1 mixture of 4-Me and 5-Me isomers, MMBIs), are also employed industrially as rubber antioxidants and are suspected to exert antithyroid toxicity such as 2-MBI. In this investigation, acute and subacute oral toxicity studies of MMBIs in Wistar rats were conducted. The clin. signs of acute oral toxicity were observed including decreased spontaneous movement, a paralytic gait, salivation and lacrimation, and adoption of prone and lateral positions. The LD50 was estimated to be 330 mg/kg. In the subacute oral toxicity study, male and female rats were treated with MMBIs by gavage at doses of 0 (corn oil), 4, 20 and 100 mg/kg for 28 consecutive days followed by a 2-wk recovery period for the control and highest dose groups. Body weight and food consumption, clin. signs, organ weights, clin. biochem. and hematol. parameters including clotting times and micronuclei induction in bone marrow erythropoietic cells, and histopathol. were examined Relative organ weights of lung, liver and kidney, and serum cholesterol and phospholipid significantly increased in male rats treated with MMBIs at doses of 20 and 100 mg/kg. Male rats administered 100 mg/kg MMBIs exhibited a 1.8-fold increase in thyroid weight associated with histopathol. changes but not altered serum thyroid hormone levels. Female rats administered 100 mg MMBIs/kg exhibited significant increases of liver and kidney but not thyroid weights, and serum cholesterol level. The antithyroid toxicity of MMBIs in rats was estimated to be one-tenth that of 2-MBI. No-observed-effect levels for male and female rats were found to be 4 and 20 mg/kg, resp., in this subacute oral toxicity study.

Compound(27231-36-3)Computed Properties of C8H8N2S received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Mercapto-5-methylbenzimidazole), if you are interested, you can check out my other related articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Electric Literature of C38H24F4O4P2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Development of ruthenium catalysts for the enantioselective synthesis of P-stereogenic phosphines via nucleophilic phosphido intermediates.

Ruthenium chiral diphosphine complexes [L2RuH][BPh4] or [(L1)(dmpe)RuH][BPh4] [L, L1 = chiral diphosphines, dmpe = 1,2-bis(dimethylphosphino)ethane] catalyze base-promoted low-temperature asym. alkylation of secondary phosphine PhMePH by benzyl halides, yielding chiral PhMe(ArCH2)P (Ar = Ph, 4-ClC6H4, 4-MeC6H4, 4-MeOC6H4, 2-MeC6H4, 1-naphthyl, 2-pyridinyl, 2-furanyl) or diphosphines PhMePCH2Ar1CH2PMePh (Ar1 = 1,3-phenylene, 1,2-phenylene, 1,3-pyridinediyl) with up to 80% ee [L = 4-iPr-2-(C6H4PPh2-2)oxazoline (iPr-PHOX) or L1 = MeO-BiPHEP, SEGPHOS]. The optimized base for the reaction was found to be sodium tert-amylate, which prevents the occurrence of background non-catalytic alkylation by deprotonation of uncoordinated PhMePH. The reactions proceed through the intermediacy of nucleophilic phosphido species, which have low barriers to pyramidal inversion; this allows for a dynamic kinetic asym. alkylation. The initially discovered [((R)-iPr-PHOX)2Ru(H)][BPh4] (6) catalyst was found to be effective in the reaction with benzylic chlorides; moreover, the alkylation displayed an unusual temperature dependence. However, the limited scope of alkylation of 6 motivated further studies which led to the development of two complementary chiral mixed ligand Ru(II) catalysts of type [L1L2Ru(H)]+. These catalysts were derived from a combination of one chiral and one achiral ligand, where a synergistic interaction of the two ligands creates an effective asym. environment around the ruthenium center. The (R)-MeO-BiPHEP catalyst [((R)-MeO-BiPHEP)(dmpe)RuH][BPh4] (10) was found to be effective for the asym. alkylation by benzyl chlorides, while the (R)-DIFLUORPHOS catalyst [[(R)-DIFLUORPHOS](dmpe)RuH][BPh4] (11) was optimal for the nucleophilic substitution of less activated alkyl bromides; the scope of the resp. catalysts was also explored.

As far as I know, this compound(503538-69-0)Electric Literature of C38H24F4O4P2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem