Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of N-Fused Benzo[4,5]imidazo[2,1-b]thiazole Derivatives via Substituted trans-1,2-Diiodoalkenes, 1H-Benzo[d]imidazole-2-thiols, and Halobenzenes, Author is Shen, Guodong; Yang, Bingchuan; Huang, Xianqiang; Hou, Yaxin; Gao, Huan; Cui, Jichun; Cui, Chuansheng; Zhang, Tongxin, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Safety of 2-Mercapto-5-methylbenzimidazole.
In the presence of CuI, 1,10-phenanthroline, and K2CO3 in DMF, 2-benzimidazolethiols underwent cross-coupling and cyclization reactions with (E)-1,2-diiodoalkenes such as (E)-PhCI:CHI to yield benzimidazothiazoles such as I (R = H) in 66-83% yields. In the presence of Pd(OAc)2, Ph3P, and Cs2CO3 in p-xylene, benzimidazothiazoles such as I (R = H) underwent arylation with aryl iodides RI (R = Ph, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-ClC6H4) and bromobenzene to yield arylbenzimidazothiazoles such as I (R = Ph, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 4-ClC6H4) in 65-96% yields. The structure of I (R = Ph) was determined by X-ray crystallog.
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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem