Nickel-Catalyzed Intermolecular Enantioselective Heteroaromatic C-H Alkylation was written by Chen, Mo;Montgomery, John. And the article was included in ACS Catalysis in 2022.Safety of 5-Methoxybenzo[d]oxazole This article mentions the following:
Herein, an approach involving nickel-catalyzed intermol. enantioselective C-H alkylation of heteroarenes, such as benzoxazoles, benzofurans, benzimidazoles, etc., with norbornene is presented. The process can be carried out under mild conditions using nickel(0) catalysts with N-heterocyclic carbene (NHC) ligands in the absence of Lewis acid co-catalysts. A series of NHC nickel complexes stabilized with 1,5-hexadiene was synthesized via an operationally simple approach, resulting in improved functional group tolerance and heteroarene scope. Mechanistic investigations are consistent with a ligand-to-ligand hydrogen transfer (LLHT) pathway where the C-H bond activation precedes a rate-determining reductive elimination step. In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3Safety of 5-Methoxybenzo[d]oxazole).
5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as anti-inflammatory, antimycobacterial, antihistamine.Safety of 5-Methoxybenzo[d]oxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem