1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
Rhodium-catalyzed ortho-amidations of sulfoximines R1C6H4S(O)(=N)R2 (R1 = H, 4-Br, 5-CH3, etc.; R2 = CH3CH2, octyl, C6H5, etc.) lead to key intermediates for the preparation of thiadiazine 1-oxides I (R = H, 4-CH3, 4-Br, 4-C6H5, 3-NO2). Following a straightforward protocol, a variety of synthetically valuable compounds can be obtained, thus circumventing common multistep approaches towards potentially bioactive products.
Rhodium-Catalyzed ortho-Amidations in the Preparation of Thiadiazine 1-Oxides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem