Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Computed Properties of C7H4ClNO3. Introducing a new discovery about 1750-45-4, Name is 5-Chloro-6-hydroxybenzo[d]oxazol-2(3H)-one
In vitro inhibitory effects of aurantio-obtusin on human liver cytochrome P450 enzymes
Aurantio-obtusin is an anthraquinone compound and possesses numerous pharmacological activities. However, whether aurantio-obtusin affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. In this study, the inhibitory effects of aurantio-obtusin on the eight human liver CYP isoforms (i.e., 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19, and 2C8) were investigated in vitro using human liver microsomes (HLMs). The results showed that aurantio-obtusin inhibited the activity of CYP1A2, 3A4, and 2E1, with IC50 values of 21.05, 13.57, and 16.12 muM, respectively, but that other CYP isoforms were not affected. Enzyme kinetic studies showed that aurantio-obtusin was not only a non-competitive inhibitor of CYP3A4, but also a competitive inhibitor of CYP1A2 and 2E1, with Ki values of 6.98, 9.52, and 8.32 muM, respectively. In addition, aurantio-obtusin is a time-dependent inhibitor for CYP3A4 with Kinact/KI value of 0.051/11.87 muM?1min?1. The in vitro studies of aurantio-obtusin with CYP isoforms indicate that aurantio-obtusin has the potential to cause pharmacokinetic drug interactions with other co-ad-ministered drugs metabolized by CYP1A2, 3A4, and 2E1. Further clinical studies are needed to evaluate the significance of this interaction.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C7H4ClNO3, you can also check out more blogs about1750-45-4
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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem