Electric Literature of 54903-16-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 54903-16-1, 2-Oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylic acid, introducing its new discovery.
Development of autotaxin inhibitors: A series of zinc binding triazoles
A series of inhibitors of Autotaxin (ATX) has been developed using the binding mode of known inhibitor, PF-8380, as a template. Replacement of the benzoxazolone with a triazole zinc-binding motif reduced crystallinity and improved solubility relative to PF-8380. Modification of the linker region removed hERG activity and led to compound 12 ? a selective, high affinity, orally-bioavailable inhibitor of ATX. Compound 12 concentration-dependently inhibits autotaxin and formation of LPA in vivo, as shown in pharmacokinetic-pharmacodynamic experiments.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 54903-16-1. In my other articles, you can also check out more blogs about 54903-16-1
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem