With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1267217-46-8,5-(Trifluoromethyl)benzo[d]oxazole,as a common compound, the synthetic route is as follows.
To a solution of 5-(trifluoromethyl)benzo[d]oxazole (2g, 10.98mmol) in dry THF (2OmL) was added LiHMDS (6 mL, 1 M in THF, 32.96mmol) at -10 00 slowly. The reaction mixture was stirred at -10 00 for 30 mm and added NBS (2.8g, 16.48mmol). The reaction mixture was allowed to come to rt and stirred for 16h. The TLC showed reaction to be complete. The reaction mixture was quenched with aq NH4CI solution (5OmL) and extracted with ethyl acetate (3x5OmL). The organic layer was washed with saturated aq NaHCO3 solution (5OmL) followed by brine (5OmL), dried (Na2SO4), filtered and concentrated under reduced pressure to give the residue. The residue was purified by column chromatography using silica gel (100-200 mesh), eluting with 3% EtOAc in hexane to afford 2-bromo-5- (trifluoromethyl)benzo[d]oxazole as a white solid. Yield: 900 mg (32%); 1H NMR (400 MHz, CDCI3): 7.99 (5, 1H), 759-7.69 (m, 2H).
1267217-46-8, The synthetic route of 1267217-46-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
Benzoxazole – Wikipedia
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