With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132244-31-6,5-Bromobenzo[d]oxazole,as a common compound, the synthetic route is as follows.
To a well stirred solution of 5-bromobenzo[JJoxazole (2.5 g, 12.6 mmol) in dry THF (25 mL) was added, 1M LiHMDS solution in THF (20.2 mL, 20.2 mmol) at -40 C dropwise and the mixture was stirred for 20 mins. To this, ethyl carbonocyanidate (1.9 g, 18.9 mmol) dissolved in THF (10 mL) was added slowly so as to attain a temperature of 0 C over a period of 1.5 h. It was again cooled to -40 C and aq. NH4C1 solution was added. The crude product was then extracted with Ethyl acetate (2 X 100 mL), dried, concentrated and purified by column chromatography to give titled compound (0.6 g, 17.6%) as pale yellow oil.
The synthetic route of 132244-31-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LUPIN LIMITED; MADAN, Sachin; TALE, Prashant, Vitthalrao; ZADE, Seema, Prabhakar; PATIL, Amolsing, Dattu; KULKARNI, Sanjeev, Anant; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2015/162538; (2015); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem