With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13673-62-6,2-(Methylthio)benzo[d]oxazole,as a common compound, the synthetic route is as follows.
(b) 6-Bromo-2-(methylthio)benzoxazole 2-(Methylthio)benzoxazole (5.8 g, see (a) above) was dissolved in chloroform (75 ml) and a solution of bromine (6.0 g) in chloroform (30 ml) was added dropwise, with stirring, over a period of 45 minutes. The mixture was allowed to stand overnight at room temperature and the solvent removed by distillation under reduced pressure to give a brown oil. The oil was washed with aqueous sodium metabisulfite and crystallized from ethanol/water to give the title compound as pink platelets (2.0 g), mp 95-96 C.
The synthetic route of 13673-62-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ICI Australia Limited; US4314065; (1982); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem