With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.177492-52-3,Benzo[d]oxazol-6-amine,as a common compound, the synthetic route is as follows.
A mixture of 5-amino-3-(trifluoromethyl)picolinonitrile (Intermediate 1 , 110 mg, 0.59 mmol), benzo[d]oxazol-6-amine (Intermediate 79, 125 mg, 0.59 mmol), and thiophosgene (0.05 mL, 0.60 mmol) in anhydrous DMA (3 mL) was stirred at 60C for 16h. Methanol (3 mL) and 2M HC1 (1.5 mL) were then added and the mixture was heated at 90C for 2h. The reaction mixture was cooled and poured into ice/water (40 mL) and the resultant solid was filtered to afford 150 mg of 5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7- yl)-3-(trifluoromethyl)picolinonitrile as a brown powder. LCMS [M + 1]+ 434.0.
177492-52-3, The synthetic route of 177492-52-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; BONNEFOUS, Celine; JULIEN, Jackaline, D.; WO2011/103202; (2011); A2;,
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