With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22876-19-3,5-Chlorobenzo[d]oxazole-2(3H)-thione,as a common compound, the synthetic route is as follows.
(1) Synthesis of 4beta-S-(6-chlorobenzoxazole-2)-podophyllotoxin: 414 mg (1 mmol) of podophyllotoxin,201 mg (1 mmol) of 6-chlorobenzoxazole-2-thiol, dried under vacuum for 1 h, using 15 mL of trifluoroacetic acid as solvent in ice bath.The mixture was stirred under vacuum for 1 to 3 hours, and chloroform acetone was used as a developing solvent to detect the end point of the reaction. Adding the reaction system to 20 to 50 times the volumeIn deionized water, the filter cake was collected by filtration and washed to obtain a crude product.
22876-19-3, The synthetic route of 22876-19-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Tang Yajie; Zhao Wei; (23 pag.)CN108285456; (2018); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem