With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22876-19-3,5-Chlorobenzo[d]oxazole-2(3H)-thione,as a common compound, the synthetic route is as follows.
22876-19-3, General procedure: A mixture of intermediate compound N-(3-(1H-tetrazole-5-yl) phenyl)-2-chloroacetamideand benzo[d]oxazole-2-thiol or benzo[d]thiazole-2-thiol or 2-mercapto benzimidazoles in anequimolar amount were taken and refluxed with acetone (20 mL) in the presence of K2CO3for 24 hr. The reaction was monitored by TLC and on completion of the reaction, an excessof solvent was evaporated at room temperature and the reaction mixture was diluted withwater (about 200 mL). The diluted hydrochloric acid was added to precipitate the productwhich was further filtered and thoroughly washed with cold water.
The synthetic route of 22876-19-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Maheshwari, Neelesh; Karthikeyan, Chandrabose; Bhadada, Shraddha V.; Verma, Amit K.; Sahi, Chandan; Moorthy, N.S. Hari Narayana; Trivedi, Piyush; Bioorganic Chemistry; vol. 92; (2019);,
Benzoxazole – Wikipedia
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