With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41014-43-1,2-(Chloromethyl)benzo[d]oxazole,as a common compound, the synthetic route is as follows.
EXAMPLE 2 3-[(2-Benzoxazolylmethyl)amino]-5-ethyl-6-methyl-2-(1H)-pyridinone A solution of 3-amino-5-ethyl-6-methyl-2-(1H)-pyridinone (152 mg,1.0 mmol), 2-chloromethyl-1,3-benzoxazole (1.07 mmol) and triethylamine (0.14 mL, 1.0 mmol) in acetonitrile (10 mmL) was stirred at reflux for 24 hrs. After concentrating under reduced pressure,the residue was flash chromatographed over silica gel. Elution with 5% MeOH- 95% CHCl3 gave 132 mg of product which was recrystallized from EtOH-water to give 95 mg of analytically pure product, mp 202-203C, with initial melting at 179 followed by resolidification. Anal. Calcd for
The synthetic route of 41014-43-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO. INC.; EP462808; (1991); A2;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem