Downstream synthetic route of 4570-41-6

The synthetic route of 4570-41-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4570-41-6,Benzo[d]oxazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: Oxazolone (2; 0.251 mmol, 1 eq) and amine nucleophile(0.326 mmol, 1.3 eq) was dissolved in toluene (1 mL) to aconcentration of 0.251 M. The reaction mixture was stirredat 70 C for 3 h, and concentrated in vacuo. The residuewas purified by flash column chromatography on silica gelusing n-heptane/EtOAc as the eluents to afford compound.

The synthetic route of 4570-41-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jo, Minmi; Won, Sun-Woo; Lee, Dong Guk; Yun, Jungeon; Kim, Sunhong; Kwak, Young-Shin; Archives of Pharmacal Research; vol. 41; 5; (2018); p. 481 – 489;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem