Downstream synthetic route of 5-Fluoro-2-methylbenzo[d]oxazole

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole,belong benzoxazole compound

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO78,mainly used in chemical industry, its synthesis route is as follows.,701-16-6

5-Fluoro-2-Methyl-6-Nitrobenzoxazole (10) Concentrated sulfuric acid (60 mL) was stirred mechanically and cooled in an ice/water bath. To this was gradually added 5-fluoro-2-methylbenzoxazole (9), (20 g, 0.132 Moles), at such a rate that the temperature stayed at 15-20 C., over a 15-20 minute period. A solution of concentrated sulfuric acid (11 mL), and concentrated nitric acid (10 mL), was prepared and added drop by drop to the benzoxazole solution at such a rate that the temperature was maintained at approximately 10 C.

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole,belong benzoxazole compound

Reference£º
Patent; Eastman Kodak Company; US2005/101784; (2005); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem