5676-60-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5676-60-8,2-Methylbenzo[d]oxazol-6-amine,as a common compound, the synthetic route is as follows.
To a solution of 2, 5-dichlorobenzenesulphonyl chloride (174 mg, 0.709 MMOL) in dichloromethane (3 mL) was added pyridine (140 pL, 1.72 MMOL) and the mixture was stirred under N2 for 5 min, after which time 6-AMINO-2-METHYLBENZOXAZOLE (100 mg, 0.675 MMOL) was added. The resulting mixture was stirred for 1 h at room temperature, then saturated NAHCO3 solution was added (8 mL) and the mixture was extracted into ethyl acetate (15 mL). The organic phase was washed with brine, dried (NA2SO4), filtered and evaporated to give a residue that was purified using flash chromatography to afford a white solid (154 mg, 64%), single spot at Rf 0.50 (60: 40 hexane: ethyl acetate). mp 167.0-167. 3C, HPLC purity 97% (tR 1.97 min in 10% WATER-ACETONITRILE).’H NMR (CDCI3) : 6 7.93 (1H, d, J=2.3 Hz), 7.47 (1H, d, J=8.6 Hz), 7.46-7. 40 (4H, m), 7.00 (1H, dd, J=8.6, 2.0 Hz), 2.61 (3H, s). LCMS: 355.07 (M-). FAB-MS (MH+, C14H10CI2N203S) : calcd 356.9867, found 356.9875.
The synthetic route of 5676-60-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; STERIX LIMITED; WO2004/37251; (2004); A1;,
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