With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5676-60-8,2-Methylbenzo[d]oxazol-6-amine,as a common compound, the synthetic route is as follows.
5676-60-8, 2,2,2-trifluoro-N-(2-methylbenzo[d]oxazol-6-yl)acetamide A solution of 2-methylbenzo[d]oxazol-6-amine (8.4 g, 56.7 mmol) in pyridine (80 mL) at 0 C. was treated with TFAA (19.8 mL, 141.0 mmol) and stirred at rt for 4 h. The reaction mixture was diluted with water (100 mL) and the product extracted with EtOAc (3*100 mL). The organics were washed with brine, dried over Na2SO4, and concentrated to obtain the crude 2,2,2-trifluoro-N-(2-methylbenzo[d]oxazol-6-yl)acetamide (15.0 g), (MS: ESI +ve, 245.20 [M-H]); 1H NMR: (400 MHz, DMSO) delta: 2.61 (s, 3H), 7.61-7.56 (m, 1H), 7.69-7.67 (d, J=8.4, 1H), 8.04-8.04 (d, J=2, 1H), 11.45 (s, 1H).
The synthetic route of 5676-60-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FLATLEY DISCOVERY LAB; Cole, Bridget M.; US2014/274933; (2014); A1;,
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