Downstream synthetic route of 6-Bromobenzo[d]oxazol-2(3H)-one

With the synthetic route has been constantly updated, we look forward to future research findings about 6-Bromobenzo[d]oxazol-2(3H)-one,belong benzoxazole compound

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO464,mainly used in chemical industry, its synthesis route is as follows.,19932-85-5

General procedure: Heteroarylboronic acid (1.3 equivalents), aryl bromide (1 equivalent), and tetrakis(triphenylphosphine) palladium(0) (5mol %) were suspended in DME to give a 0.07-0.1M solution of boronic acid under nitrogen atmosphere. A 0.5M aqueous solution of sodium carbonate (6 equivalents) was added. The mixture was refluxed for 3.5-14h, cooled to room temperature, diluted with water and extracted several times with ethyl acetate. The combined extracts were dried over anhydrous MgSO4, concentrated and purified by flash chromatography and were if necessary recrystallized.

With the synthetic route has been constantly updated, we look forward to future research findings about 6-Bromobenzo[d]oxazol-2(3H)-one,belong benzoxazole compound

Reference£º
Article; Grombein, Cornelia M.; Hu, Qingzhong; Rau, Sabrina; Zimmer, Christina; Hartmann, Rolf W.; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 788 – 796;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem