With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64037-15-6,5-Methyl-2-aminobenzoxazol,as a common compound, the synthetic route is as follows.,64037-15-6
To a 50 ml three-necked flask was added 5-methylbenzoxazol-2-amine, 10 ml of tetrahydrofuran, 5 ml of triethylamine. The acid chloride was then dissolved in 10 ml of dry tetrahydrofuran, Below 5 deg C under the conditions of slow drop, The reaction was stirred at room temperature for 4 h. 40 ml of saturated aqueous sodium chloride solution was added,The aqueous phase was extracted three times with 25 ml of dichloromethane, Combine the organic phase. Column separation, Dichloromethane: methanol 60: 1 to give 1.39 g of a white solid, M.p. 174 to 176 C, yield: 70.6%.
The synthetic route of 64037-15-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences; Si, Shuyi; Gao, Nana; Jiang, Wei; Jiang, Jiandong; Li, Yan; Li, Dongsheng; Li, Yongzhen; Zhang, Jing; Zhu, Ningyu; Wang, Zhimin; (20 pag.)CN103772376; (2017); B;,
Benzoxazole – Wikipedia
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