As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO203,mainly used in chemical industry, its synthesis route is as follows.,924869-17-0
At 20 from Preparative Example 1The obtained methylbenzo [d] oxazole-5-carboxylate 354.1 mg (2.0 mmol) was dissolved in toluene (20 mL, 0.1 M)4-Bromophenol (380.6 mg, 2.2 mmol), Palladium acetate (Pd (OAc) 2, 4.5 mg, 1 mol%),Copper acetate monohydrate (Cu (OAc) 2 .H2O, 72.6 mg, 20 mol%),Tricyclohexylphosphine (PCy3, 280.4 mg, 50 mol%) And potassium carbonate (K2CO3, 552.8 mg, 4 mmol) were slowly added.The reaction mixture was reacted in a microwave at 160 C for 0.5 hour under a condition of 200W, The reaction was terminated by the addition of aqueous ammonium chloride solution, Ethyl acetate (10 mL) was extracted and extracted three times. After the water of the organic layer was removed with sodium sulfate,The solvent was concentrated with a vacuum distillation apparatus.The residue was purified by silica gel chromatography to give the title compoundMethyl 2- (4-hydroxyphenyl) benzo [d] oxazole-5-carboxylate(360.6 mg, 67%) was obtained
With the complex challenges of chemical substances, we look forward to future research findings about Methyl benzo[d]oxazole-5-carboxylate,belong benzoxazole compound
Reference£º
Patent; Korea Institute of Science and Technology; Ham Jeong-yeop; Kim Tae-jeong; Park Yeong-tae; Kim Yeong-ju; Lee Jae-uk; Noh Tae-seop; Hwang Byeong-su; Kim Gyu-seon; (27 pag.)KR101792743; (2017); B1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem