Synthesis and anticancer activity of glycol-bridged bis-benzimidazoles was written by El-Kihel, Abdellatif;Jebbari, Said;Ahbala, Mustapha;Ait, Houssine Sir;Schmitt, Florian;Gold, Madeleine;Bauchat, Patrick;Schobert, Rainer;Biersack, Bernhard. And the article was included in DJ Journal of Engineering Chemistry and Fuel in 2019.Electric Literature of C8H7NOS This article mentions the following:
A series of bis-benzimidazoles with polyglycol-sulfide linker I [R = H, Me, F, NO2; R1 = H, Me; X = S, O, NH, N-propargyl; n = 1, 2] was prepared and tested for their tumor cell growth inhibitory activities. Two derivatives I [R = R1 = H, X = NH, n = 1; R = R1 = H, X = NH, n = 2] showed significant growth inhibitory activities against 518A2 melanoma cells. In addition, these compounds were active against multidrug resistant KB-V1Vbl cervix carcinoma cells (vinblastine-resistant cells with overexpressed P-gp transporter) and MCF-7Topo breast carcinoma cells (topotecan-resistant cells with overexpressed BCRP transporter). Thus, valuable lead structures for the design of new anticancer drugs based on benzimidazole systems were identified that could overcome drug resistance. In the experiment, the researchers used many compounds, for example, 6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0Electric Literature of C8H7NOS).
6-Methyl-1,3-benzoxazole-2-thiol (cas: 23417-29-0) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Electric Literature of C8H7NOS
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem