22876-22-8, Name is 5-Methylbenzo[d]oxazole-2(3H)-thione, belongs to benzoxazole compound, is a common compound. Application In Synthesis of 5-Methylbenzo[d]oxazole-2(3H)-thioneIn an article, once mentioned the new application about 22876-22-8.
Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl) phenyl]acetamide derivatives containing (benz)azole moiety
A new class of novel thiazole-(benz)azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, 1H-NMR, and MS spectral data and elemental analyses. Anticancer effect of the compounds was evaluated against A549 and C6 tumor cell lines. MTT, analysis of DNA synthesis, acridine orange/ethidium bromide staining method and analysis of caspase-3 activation assays were performed for anticancer activity investigations. Compounds 6f and 6g, which carry 5-chloro and 5-methylbenzimidazole groups showed significant anticancer activity. Potential of these compounds to direct tumor cells to apoptotic pathway, which is a precondition of anticancer action, was also observed.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem