Formula: C38H24F4O4P2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Computational Analysis of Enantioselective Pd-Catalyzed α-Arylation of Ketones. Author is Orlandi, Manuel; Licini, Giulia.
The direct α-arylation of carbonyl compounds emerged over the last two decades as a straightforward method for the formation of C(sp3)-C(sp2) bonds. Mechanistic studies suggested a classical cross-coupling catalytic cycle. This consists of oxidative addition of the aryl halide (ArX) to the Pd(0)-catalyst, transmetalation of the Na- or K-enolate generated in situ, and subsequent reductive elimination. Even though the general reaction mechanism was thoroughly investigated, studies focusing on enantioselective variants of this transformation are rare. Here, the computational study of the [Pd(BINAP)]-catalyzed α-arylation of 2-methyltetralone with bromobenzene is reported. The whole reaction energy profile was computed and several mechanistic scenarios were investigated for the key steps of the reaction, which are the enolate transmetalation and the C-C bond-forming reductive elimination. Among the computed mechanisms, the reductive elimination from the C-bound enolate Pd complex was found to be the most favorable one, providing a good match with the stereoselectivity observed exptl. with different ligands and substrates. Detailed anal. of the stereodetermining transition structures allowed us to establish the origin of the reaction enantioselectivity.
If you want to learn more about this compound((R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole)Formula: C38H24F4O4P2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(503538-69-0).
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem