Research speed reading in 2021. Catalysts allow a reaction to proceed that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 1714-29-0, Name is 1-Bromopyrene, molecular formula is , belongs to benzoxazole compound. In a document, author is Saranya, Thachora Venu, Quality Control of 1-Bromopyrene.
Development of newer methods for the synthesis of Benzoxazoles has of greater interest due to their wide range of biological activities and pharmaceutical importance. We herein report a facile and general method for the synthesis of 2-substituted Benzoxazoles via copper catalyzed intramolecular C-O cross-coupling of 2-haloanilides. A combination of CuI (5 mol%), 2,2′-bipyridine (10 mol%), Cs2CO3 (2 equiv.) in DMF solvent with 4 angstrom molecular sieves at 140 degrees C, illustrated the scope for tuning the reactivity of 2-haloanilides toward the selective formation of a series of 2-alkyl benzoxazole derivatives in moderate to good yields. This is the first systematic study using CuI/2,2′-Bipyridine as the catalytic system for the synthesis of 2-substituted Benzoxazoles. The outcome of the reaction was found to be significantly influenced by the aromatic and amide substituents of 2-haloanilides. [GRAPHICS]
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 1714-29-0, you can contact me at any time and look forward to more communication. Quality Control of 1-Bromopyrene.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem