Synthetic Route of 112704-79-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 112704-79-7, Name is 4-Bromo-2-fluorobenzoic acid, SMILES is O=C(O)C1=CC=C(Br)C=C1F, belongs to benzoxazole compound. In a article, author is Tariq, Sana, introduce new discover of the category.
Synthesis, p38 MAP kinase inhibition, anti-inflammatory activity, and molecular docking studies of 1,2,4-triazole-based benzothiazole-2-amines
Recent studies have demonstrated that inhibition of p38 MAP kinase could effectively inhibit pro-inflammatory cytokines including TNF- and interleukins. Thus, inhibition of this enzyme can prove greatly beneficial in the therapy of chronic inflammatory diseases. A new series of N-[3-(substituted-4H-1,2,4-triazol-4-yl)]-benzo[d]thiazol-2-amines (4a-n) were synthesized and subjected to in vitro evaluation for anti-inflammatory activity (BSA anti-denaturation assay) and p38 MAPK inhibition. Among the compounds selected for in vivo screening of anti-inflammatory activity (4b, 4c, 4f, 4g, 4j, 4m, and 4n), compound 4f was found to be the most active with an in vivo anti-inflammatory efficacy of 85.31% when compared to diclofenac sodium (83.68%). It was also found to have a low ulcerogenic risk and a protective effect on lipid peroxidation. The p38 MAP kinase inhibition of this compound (IC50=0.036 +/- 0.12M) was also found to be superior to the standard SB203580 (IC50=0.043 +/- 0.27M). Furthermore, the in silico binding mode of the compound on docking against p38 MAP kinase exemplified stronger interactions than those of SB203580.
Synthetic Route of 112704-79-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 112704-79-7.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem