Reference of (1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid, is researched, Molecular C13H15BFNO4, CAS is 1000068-26-7, about Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists. Author is Bakir, Farid; Kher, Sunil; Pannala, Madhavi; Wilson, Norma; Nguyen, Trang; Sircar, Ila; Takedomi, Kei; Fukushima, Chiaki; Zapf, James; Xu, Kui; Zhang, Shao-Hui; Liu, Juping; Morera, Lisa; Schneider, Lisa; Sakurai, Naoki; Jack, Rick; Cheng, Jie-Fei.
A structurally novel liver X receptor (LXR) agonist (I) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. I increased ABCA1 gene expression by eightfold and SREBP1c by threefold in differentiated THP-1 macrophage cell lines. Confirmation of its agonistic activity against LXR was obtained in the co-factor recruitment and reporter transactivation assays. Structure-activity relation studies on I are described.
There is still a lot of research devoted to this compound(SMILES：C(=O)(OC(C)(C)C)[N]2C1=CC(=CC=C1C=C2B(O)O)F)Reference of (1-(tert-Butoxycarbonyl)-6-fluoro-1H-indol-2-yl)boronic acid, and with the development of science, more effects of this compound(1000068-26-7) can be discovered.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem