6-Bromobenzo[d]oxazol-2(3H)-one, cas is 19932-85-5, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,19932-85-5
To a solution of the compound of Preparation A (0.348 g; l . lmmol) and 6-bromobenzo[< Joxazol-2(3H)-one (prepared as described in EP 1988077, 0.214 g; lmmol) in DMF (4.2 mL) was added K2C03 (0.212g, 1.53mmol). The reaction proceeded at 60C for 16h. Water (20 mL) was added and the resulting mixture was extracted three times with EA (3 x 20 mL). The evaporation residue was purified by CC (EA-Hept) to afford the title compound (0.396 g; 88% yield) as an orange solid. 1H NMR (d6-DMSO) delta 7.69 (d, J = 1.8 Hz, 1H); 7.47 (dd, J = 1.8, 8.3 Hz, 1 H); 7.30 (d, J = 8.3 Hz, 1H); 4.00-3.91 (overlapped m, 1H); 3.91-3.81 (overlapped m, 1H); 3.1 1 (s, 3H); 2.66-2.56 (m, 1H); 2.19-2.10 (m, 1H); 1.58 (s, 3H); 1.35 (s, 9H). MS (ESI, m/z): 448.04 [M+H+] for Ci7H22N06BrS; tR = 0.92 min.
As the rapid development of chemical substances, we look forward to future research findings about 19932-85-5
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; CHAPOUX, Gaelle; DIETHELM, Stefan; GAUVIN, Jean-Christophe; PANCHAUD, Philippe; SURIVET, Jean-Philippe; (90 pag.)WO2017/37039; (2017); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem