Extracurricular laboratory: Synthetic route of 375369-14-5

375369-14-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,375369-14-5 ,6-Bromobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Name is 6-Bromobenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 375369-14-5, its synthesis route is as follows.

6-Bromobenzo[d]oxazole (0.600 g, 3.03 mmol), anhydrous potassium acetate (0.595 g, 6.06 mmol) and 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (0.846 g, 3.33 mmol) were combined in dry dioxane (10 mL), and the mixture was sparged with nitrogen for 15 min. The reaction mixture was treated with Pd(dppf)Cl2 (0.124 mg, 0.152 mmol) and was heated to 90C for 16 h After cooling, the mixture was shaken with EtOAc (45 mL) and satd NaCl (10 mL) and was filtered to remove dark solids. The organic phase was dried and concentrated. Purification by silica gel chromatography with 0-30% EtOAc-hexane afforded the title compound as white crystals (600 mg, 74%): mp 79-81 C; NMR (400 MHz, CDCl3) delta 8.13 (s, 1H), 8.04 (s, 1H), 7.80 (qt, / = 3.3, 1.8 Hz, 2H), 1.37 (s, 12H); EIMS m/z 245.

375369-14-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,375369-14-5 ,6-Bromobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference:
Patent; DOW AGROSCIENCES LLC; BELL, Jared; BUYSSE, Ann M.; DAEUBLE, John F.; ECKELBARGER, Joseph D.; EPP, Jeffrey B.; IRVINE, Nicholas M.; KISTER, Jeremy; LO, William C.; LOSO, Michael R.; LOWE, Christian T.; ROHANNA, John C.; SATCHIVI, Norbert M.; SIDDALL, Thomas L.; STEWARD, Kimberly M.; YERKES, Carla N.; (281 pag.)WO2019/84353; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem