Extracurricular laboratory: Synthetic route of 503538-69-0

In some applications, this compound(503538-69-0)Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, is researched, Molecular C38H24F4O4P2, CAS is 503538-69-0, about Efficient access to bicyclo[4.3.0]nonanes: copper-catalyzed asymmetric silylative cyclization of cyclohexadienone-tethered allenes. Author is He, Zhi-Tao; Tang, Xiao-Qi; Xie, Li-Bo; Cheng, Mian; Tian, Ping; Lin, Guo-Qiang.

The creation of three consecutive chiral carbon centers in one step is achieved using Cu-catalyzed asym. silylative cyclization of cyclohexadienone-tethered allenes I (1a-x), in reaction with PhMe2SiBpin (2), catalyzed by CuCl/L or CuCl/L2 (L = BINOL phosphoramidite; L2 = BIPHEP, Segphos, Difluorphos, P-Phos, etc.), giving bicyclic enones II (3a-x; X = O, NBoc, CH2; R = Me, Cy, PhCH2, BocNHCH2CH2, alkoxy, CH2:CH, Ph, MeO2CCH2, haloalkyl, aryl); the products 3 were obtained with >90% ee, either as pure diastereomer or with (15-20):1 ratio of (3S,3aR,7aR):(3S,3aS,7aS) diastereomers. The requisite allenyl-tethered cyclohexadienones 1a-r were prepared by oxidative etherification of phenols 4-RC6H4OH with propargyl alc. CHCCH2OH to give cyclohexadienone propargyl ethers HCCCH2O(R)(CH:CH)2CO with subsequent CuBr-catalyzed formaldehyde addition Through regioselective β-silylation of the allene and subsequent enantioselective 1,4-addition to cyclohexadienone, this tandem reaction could afford cis-hydrobenzofuran, cis-hydroindole, and cis-hydroindene frameworks with excellent yields (80-98%) and enantioselectivities (94-98 % ee) bearing vinylsilane and enone substructures. Meanwhile, this mild transformation is generally compatible with a wide range of functional groups, which allows further conversion of the bicyclic products to bridged and tricyclic ring structures.

In some applications, this compound(503538-69-0)Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem