Continuous flow/waste-minimized synthesis of benzoxazoles catalysed by heterogeneous manganese systems was written by Ferlin, Francesco;van der Hulst, Mitchell K.;Santoro, Stefano;Lanari, Daniela;Vaccaro, Luigi. And the article was included in Green Chemistry in 2019.Application of 99586-31-9 This article mentions the following:
Herein, we present our results on the development of a waste minimized protocol for the synthesis of 2-arylbenzoxazoles in continuous flow. Manganese-based heterogeneous catalysts were used in combination with cyclopentylmethyl ether as an environmentally friendly and safe reaction medium. The use of oxygen promotes the oxidative process ensuring at the same time a complete regeneration of the catalyst adopting a flow configuration which does not include the use of an addnl. mech. pump. These features allowed for a faster synthesis compared to batch procedures with minimal metal leaching. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application of 99586-31-9).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Application of 99586-31-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem