Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.348-54-9, Name is 2-Fluoroaniline, SMILES is NC1=CC=CC=C1F, belongs to benzoxazole compound. In a document, author is Zheng, Ling-Li, introduce the new discover, Computed Properties of C6H6FN.
Pd/Cu bimetallic co-catalyzed direct 2-arylation of benzoxazole with aryl chloride
An efficient Palladium/Copper bimetallic co-catalyzed direct 2-arylation of benzoxazoles with aryl chlorides is presented. The Pd(OAc)(2)/Cul/NiXantphos-based catalyst enables the installation of various aryl and heteroaryl groups in good to excellent yields (75-99%). Preliminary mechanism investigation indicates that Pd/Nixantphos complex activates C-Cl bond of aryl chlorides via oxidative addition, and Cu/Nixantphos complex chelates with nitrogen atom to lower the pK(a) of the 2-H in benzoxazoles. (C) 2019 Elsevier Ltd. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 348-54-9 is helpful to your research. Computed Properties of C6H6FN.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem