Catalytic Direct C2-Alkenylation of Oxazoles at Parts per Million Levels of Palladium/PhMezole-Phos Complex was written by Fu, Wai Chung;Wu, Yong;So, Chau Ming;Wong, Shun Man;Lei, Aiwen;Kwong, Fuk Yee. And the article was included in Organic Letters in 2016.COA of Formula: C8H7NO2 This article mentions the following:
General direct C2-alkenylation of oxazoles is reported using alkenyl tosylates at ppm levels of palladium catalyst. From a series of ligands screened, PhMezole-Phos emerged as the promising ligand candidate to facilitate this reaction. Significantly, the method is scalable and exhibits excellent substrate tolerance. Highly sterically hindered substrates and small vinyl tosylate can be coupled successfully. Moreover, our method enables a rapid diversification of oxazole-based C^N ligands which can be readily derived into new group 9 organometallic compounds In the experiment, the researchers used many compounds, for example, 5-Methoxybenzo[d]oxazole (cas: 132227-03-3COA of Formula: C8H7NO2).
5-Methoxybenzo[d]oxazole (cas: 132227-03-3) belongs to benzoxazole derivatives. Benzoxazoles belong to the group of well-known antifungal agents with antioxidant, antiallergic, antitumoral and antiparasitic activity. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.COA of Formula: C8H7NO2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem