1-Iminotetrahydrothiophene 1-oxide (BD00963737) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
The preparation and dielec. constants of di-Me sulfoximide (I), tetramethylene sulfoximide, and di-Me N-methylsulfoximide are reported, and the kinetics examined for typical nucleophilic substitution and base-catalyzed elimination reactions in I as solvent. The rate enhancements indicate that the sulfoximides belong to a new type of solvent which is protic but behaves like a characteristic polar aprotic solvent. Also reported is the solvolysis of alkyl toluenesulfonates and halides in I to give the corresponding N-alkyl sulfoximides. Thus, octyl toluenesulfonate was heated in I at 95¡ã for 20 h to give 83% di-Me N-octylsulfoximide.
Enhanced reactivities in substitution and elimination reactions in dimethyl sulfoximide. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 145026-07-9
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem