S8-Mediated Cyclization of 2-Aminophenols/thiophenols with Arylmethyl Chloride: Approach to Benzoxazoles and Benzothiazoles was written by Gan, Haifeng;Miao, Dazhuang;Pan, Qiang;Hu, Renhe;Li, Xiaotong;Han, Shiqing. And the article was included in Chemistry – An Asian Journal in 2016.Category: benzoxazole This article mentions the following:
A metal-free approach to benzazoles I (R1 = H, 5-CH3, 5-OCH3, 4-Cl, 4-F; R2 = naphthalen-1-yl, pyridin-4-yl, 3-OCH3, etc.; X = O, S) from 2-mercaptan/2-hydroxyanilines R1-2-NH2C6H3XH and arylmethyl chlorides R2CH2Cl using elemental sulfur as a traceless oxidizing agent has been developed. The reactions proceeded in good to excellent yields, exhibiting good functional groups tolerance and gram-scale ability. A key mechanistic investigation indicated that the key intermediate 2,2′-trisulfanediyldianiline, which was characterized by NMR, HRMS and crystal X-ray crystallog., was separated in the reaction prior to the formation of the product I. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Category: benzoxazole).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. Although benzoxazole itself is of little practical value, many derivatives of benzoxazoles are commercially important. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antiparkinson, inhibition of hepatitis C virus, 5-HT3 antagonistic effect.Category: benzoxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem