Facile Preparation of Benzoxazoles from S8-Promoted Cyclization of 2-Nitrophenols with Arylmethyl Chloride was written by Gan, Haifeng. And the article was included in ChemistrySelect in 2019.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole This article mentions the following:
A simple, metal-free methodol. has been obtained for the preparation of 2-arylbenzoxazoles I (R = H, 6-Me, 5-NHC(O)CH3, etc.; R1 = Ph, naphthalen-2-yl, pyridin-4-yl, etc.) from 2-nitrophenols 2-NO2-R2 -C6H3OH (R = H, 5-Me, 4-F, etc.) and arylmethyl chlorides R1CH2Cl via an elemental sulfur-promoted cyclization reaction. The reactions proceeded in moderate to good yields, and gram-scale is applicable. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole).
2-(3-Bromophenyl)benzo[d]oxazole (cas: 99586-31-9) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Application In Synthesis of 2-(3-Bromophenyl)benzo[d]oxazole
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem