Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities was written by Ge, Jian-Feng;Zhang, Qian-Qian;Lu, Jian-Mei;Kaiser, Marcel;Wittlin, Sergio;Brun, Reto;Ihara, Masataka. And the article was included in MedChemComm in 2012.Electric Literature of C9H9NO This article mentions the following:
Six cyanine dyes (including sym. and unsym. trimethine and pentamethine cyanine dyes with substituted benzoxazolyl or benzothiazolyl groups), were synthesized and evaluated for their in-vitro antiprotozoal activities against Plasmodium falciparum K1, Trypanosoma cruzi, Trypanosoma brucei rhodesiense and Leishmania donovani. Several trimethine cyanine dyes containing benzothiazole groups exhibited strong activity against Plasmodium falciparum and Trypanosoma cruzi, while one sym. pentamethine cyanine containing a fluorinated benzothiazolyl group was highly active against Trypanosoma brucei rhodesiense. The title compounds thus formed included a benzothiazole-benzothiazolium derivative (I) [[(benzothiazolylidene)pentadienyl]benzothiazolium salt, pentamethine compound] and related compounds and benzoxazole analogs. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. A number of marketed drugs are available having benzoxazole as core active moiety like, nonsteroidal anti-inflammatory drug (NSAID)—flunoxaprofen, benoxaprofen, antibiotic—calcimycin.Electric Literature of C9H9NO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem