In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Furan compounds. III. A new synthesis of furyl ketones, published in 1950, which mentions a compound: 3194-15-8, mainly applied to , Safety of 1-(Furan-2-yl)propan-1-one.
cf. C.A. 44, 2973d. Several furyl ketones were synthesized from furyl aldehydes and diazoalkanes as starting materials. The aldehydes were treated in dry Et2O, free of alcs., with 1.5 equivalents diazoalkane at room temperature for 2-14 days and the ketones distilled The following ketones are reported: 2-acetylfuran (70-75% yield), from furfural (I) and CH2N2 (II) after 12 days, b. 169-73° (semicarbazone, m. 148°); 2-propionylfuran, in nearly quant. yield from I and MeCHN2 (III) in 2-3 days, b. 182-3°, m. 28-30° (semicarbazone, m. 189°); 5-methyl-2-propionylfuran (IV), in nearly quant. yield from 5-methylfurfural and III in 2-3 days, b14 94-6° (semicarbazone, m. 162-4°; oxime, prepared by boiling 1.5 g. ketone, 1 g. HONH2.HCl, and 1 g. AcONa for 4 h., and addition of H2O, m. 110°); 5-hydroxymethyl-2-acetylfuran, prepared in 40% yield from 5-(hydroxymethyl)furfural and II after 14 days, b. 130° [semicarbazone, m. 194° (from dilute EtOH)]. IV is a new compound 5-Methylfurfural remained unchanged after 3 wk with I in Et2O.
After consulting a lot of data, we found that this compound(3194-15-8)Safety of 1-(Furan-2-yl)propan-1-one can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem