Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 367-11-3, Name is 1,2-Difluorobenzene, molecular formula is , belongs to benzoxazole compound. In a document, author is Lu, Ju-You, Recommanded Product: 367-11-3.
Ligand-free synthesis of 2-aminoarylbenzoxazoles via copper-catalyzed C-N/C-O coupling
A copper-catalyzed C-N/C-O coupling has been developed for synthesis of 2-aminoarylbenzoxazole derivatives. The protocol uses readily available 2-halo-N-(2-halophenyl)benzamides and amines as the starting materials, and the corresponding 2-aminoarylbenzoxazoles were obtained in good to excellent yields. Both aromatic and aliphatic amines were tolerated, and no ligand was used in this reaction. Gram-scale synthesis was also carried out successfully. These results showed the potential synthetic value of this new reaction in organic synthesis. (C) 2020 Elsevier Ltd. All rights reserved.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem