Intermaggio, Nicholas E. published the artcileDeoxytrifluoromethylation of Alcohols, Application of 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, the publication is Journal of the American Chemical Society (2022), 144(27), 11961-11968, database is CAplus and MEDLINE.
Deoxy-functionalization of alcs. represents a class of reactions that has had profound impact on modern medicine. In particular, deoxyfluorination is commonly employed as a means to incorporate high-value fluorine atoms into drug-like mols. Recently, the trifluoromethyl (CF3) group has garnered attention from medicinal chemists due to its ability to markedly improve the pharmaceutical properties of small mol. drug candidates. To date, however, there remains no general means to accomplish the analogous deoxygenative trifluoromethylation of alcs. Herein, a copper metallaphotoredox-mediated direct deoxytrifluoromethylation is reported, wherein alc. substrates are activated in situ by benzoxazolium salts for C(sp3)-CF3 bond formation.
Journal of the American Chemical Society published new progress about 1207294-92-5. 1207294-92-5 belongs to benzoxazole, auxiliary class Achiral NHCs Ligands, name is 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate, and the molecular formula is C21H26BF4NO, Application of 5,7-Di-tert-butyl-3-phenylbenzo[d]oxazol-3-ium tetrafluoroborate.
Referemce:
https://en.wikipedia.org/wiki/Benzoxazole,
Benzoxazole | C7H5NO – PubChem